Pre- and Postnatal Neuroimaging of Congenital Cerebellar Abnormalities

Andrea Poretti, Eugen Boltshauser, Thierry A G M Huisman

Research output: Contribution to journalArticle

Abstract

The human cerebellum has a protracted development that makes it vulnerable to a broad spectrum of developmental disorders including malformations and disruptions. Starting from 19 to 20 weeks of gestation, prenatal magnetic resonance imaging (MRI) can reliably study the developing cerebellum. Pre- and postnatal neuroimaging plays a key role in the diagnostic work-up of congenital cerebellar abnormalities. Diagnostic criteria for cerebellar malformations and disruptions are based mostly on neuroimaging findings. The diagnosis of a Dandy-Walker malformation is based on the presence of hypoplasia, elevation, and counterclockwise upward rotation of the cerebellar vermis and cystic dilatation of the fourth ventricle, which extends posteriorly filling out the posterior fossa. For the diagnosis of Joubert syndrome, the presence of the molar tooth sign (thickened, elongated, and horizontally orientated superior cerebellar peduncles and an abnormally deep interpeduncular fossa) is needed. The diagnostic criteria of rhombencephalosynapsis include a complete or partial absence of the cerebellar vermis and continuity of the cerebellar hemispheres across the midline. Unilateral cerebellar hypoplasia is defined by the complete aplasia or hypoplasia of one cerebellar hemisphere. Familiarity with these diagnostic criteria as well as the broad spectrum of additional neuroimaging findings is important for a correct pre- and postnatal diagnosis. A correct diagnosis is essential for management, prognosis, and counseling of the affected children and their family.

Original languageEnglish (US)
Pages (from-to)5-9
Number of pages5
JournalCerebellum
Volume15
Issue number1
DOIs
StatePublished - Feb 1 2016

Fingerprint

Neuroimaging
Cerebellum
Dandy-Walker Syndrome
Fourth Ventricle
Prenatal Diagnosis
Counseling
Dilatation
Tooth
Magnetic Resonance Imaging
Pregnancy
Cerebellar Hypoplasia
Cerebellar Vermis
Recognition (Psychology)
Joubert syndrome 1

Keywords

  • Cerebellum
  • Fetal
  • Malformations
  • Neuroimaging

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Pre- and Postnatal Neuroimaging of Congenital Cerebellar Abnormalities. / Poretti, Andrea; Boltshauser, Eugen; Huisman, Thierry A G M.

In: Cerebellum, Vol. 15, No. 1, 01.02.2016, p. 5-9.

Research output: Contribution to journalArticle

Poretti, Andrea ; Boltshauser, Eugen ; Huisman, Thierry A G M. / Pre- and Postnatal Neuroimaging of Congenital Cerebellar Abnormalities. In: Cerebellum. 2016 ; Vol. 15, No. 1. pp. 5-9.
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