Pre- and postmortem imaging of transplanted cells

Anna Andrzejewska, Adam Nowakowski, Miroslaw Janowski, Jeff W.M. Bulte, Assaf A. Gilad, Piotr Walczak, Barbara Lukomska

Research output: Contribution to journalReview article

Abstract

Therapeutic interventions based on the transplantation of stem and progenitor cells have garnered increasing interest. This interest is fueled by successful preclinical studies for indications in many diseases, including the cardiovascular, central nervous, and musculoskeletal system. Further progress in this field is contingent upon access to techniques that facilitate an unambiguous identification and characterization of grafted cells. Such methods are invaluable for optimization of cell delivery, improvement of cell survival, and assessment of the functional integration of grafted cells. Following is a focused overview of the currently available cell detection and tracking methodologies that covers the entire spectrum from pre- to postmortem cell identification.

Original languageEnglish (US)
Pages (from-to)5543-5559
Number of pages17
JournalInternational journal of nanomedicine
Volume10
DOIs
StatePublished - Sep 2 2015

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Keywords

  • Bioluminescence
  • Cell labeling
  • MRI
  • SPECT
  • Stem cells
  • Transplantation

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

Cite this

Andrzejewska, A., Nowakowski, A., Janowski, M., Bulte, J. W. M., Gilad, A. A., Walczak, P., & Lukomska, B. (2015). Pre- and postmortem imaging of transplanted cells. International journal of nanomedicine, 10, 5543-5559. https://doi.org/10.2147/IJN.S83557