Pre-analytic considerations for the proper assessment of hormones of the hypothalamic-pituitary axis in epidemiological research

Rachel L. Derr, Scott J. Cameron, Sherita Hill Golden

Research output: Contribution to journalReview article

Abstract

There is growing epidemiological interest in hormones as predictors of chronic diseases. The correct handling and analysis of hormones can be cumbersome, and great care must be taken in these processes in order to gain the most information possible. Given differences in sampling, processing, and stability of the various hormonal assays, we sought to provide a comprehensive review to aid future epidemiological research. We have coupled a thorough literature search with our own analytical experience to outline common laboratory problems one must consider in analyzing the hormones of the hypothalamic-pituitary axis. In addition, we describe the benefits and limitations of using alternative media - including urine, saliva, and blood spots on filter paper - to measure endocrine hormones in epidemiological studies.

Original languageEnglish (US)
Pages (from-to)217-226
Number of pages10
JournalEuropean Journal of Epidemiology
Volume21
Issue number3
DOIs
StatePublished - Mar 1 2006

Keywords

  • Biological assay
  • Epidemiology
  • Hormones
  • Immunoassay
  • Saliva
  • Storage

ASJC Scopus subject areas

  • Epidemiology

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