Prazosin selectively antagonizes neuronal responses mediated by α1-adrenoceptors in brain

David B. Menkes; Jay M. Baraban; George K. Aghajanian

doi:10.1007/BF00503830

Prazosin selectively antagonizes neuronal responses mediated by α₁-adrenoceptors in brain

David B. Menkes, Jay M. Baraban, George K. Aghajanian

Research output: Contribution to journal › Article › peer-review

104 Scopus citations

Abstract

The ability of systemically and locally administered prazosin to block α₁-adrenoceptors was examined in two brain areas in the rat. Using single unit recording of neurons in the lateral geniculate and dorsal raphe nuclei, evidence was obtained for the selective blockade of α₁-adrenoceptors by both intravenous and iontophoretic prazosin. Since effective systemic doses of prazosin were within the clinical range, it appears likely that brain α₁-adrenoceptors would be blocked during prazosin therapy in humans.

Original language	English (US)
Pages (from-to)	273-275
Number of pages	3
Journal	Naunyn-Schmiedeberg's Archives of Pharmacology
Volume	317
Issue number	3
DOIs	https://doi.org/10.1007/BF00503830
State	Published - Nov 1981
Externally published	Yes

Keywords

Antihypertensive
Norepinephrine
Prazosin
Single unit
α-adrenoceptors

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1007/BF00503830

Cite this

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title = "Prazosin selectively antagonizes neuronal responses mediated by α1-adrenoceptors in brain",

abstract = "The ability of systemically and locally administered prazosin to block α1-adrenoceptors was examined in two brain areas in the rat. Using single unit recording of neurons in the lateral geniculate and dorsal raphe nuclei, evidence was obtained for the selective blockade of α1-adrenoceptors by both intravenous and iontophoretic prazosin. Since effective systemic doses of prazosin were within the clinical range, it appears likely that brain α1-adrenoceptors would be blocked during prazosin therapy in humans.",

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AU - Baraban, Jay M.

AU - Aghajanian, George K.

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N2 - The ability of systemically and locally administered prazosin to block α1-adrenoceptors was examined in two brain areas in the rat. Using single unit recording of neurons in the lateral geniculate and dorsal raphe nuclei, evidence was obtained for the selective blockade of α1-adrenoceptors by both intravenous and iontophoretic prazosin. Since effective systemic doses of prazosin were within the clinical range, it appears likely that brain α1-adrenoceptors would be blocked during prazosin therapy in humans.

AB - The ability of systemically and locally administered prazosin to block α1-adrenoceptors was examined in two brain areas in the rat. Using single unit recording of neurons in the lateral geniculate and dorsal raphe nuclei, evidence was obtained for the selective blockade of α1-adrenoceptors by both intravenous and iontophoretic prazosin. Since effective systemic doses of prazosin were within the clinical range, it appears likely that brain α1-adrenoceptors would be blocked during prazosin therapy in humans.

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KW - Norepinephrine

KW - Prazosin

KW - Single unit

KW - α-adrenoceptors

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