Prazosin selectively antagonizes neuronal responses mediated by α1-adrenoceptors in brain

David B. Menkes, Jay M. Baraban, George K. Aghajanian

Research output: Contribution to journalArticlepeer-review


The ability of systemically and locally administered prazosin to block α1-adrenoceptors was examined in two brain areas in the rat. Using single unit recording of neurons in the lateral geniculate and dorsal raphe nuclei, evidence was obtained for the selective blockade of α1-adrenoceptors by both intravenous and iontophoretic prazosin. Since effective systemic doses of prazosin were within the clinical range, it appears likely that brain α1-adrenoceptors would be blocked during prazosin therapy in humans.

Original languageEnglish (US)
Pages (from-to)273-275
Number of pages3
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Issue number3
StatePublished - Nov 1981
Externally publishedYes


  • Antihypertensive
  • Norepinephrine
  • Prazosin
  • Single unit
  • α-adrenoceptors

ASJC Scopus subject areas

  • Pharmacology


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