Practice Patterns of Stereotactic Radiotherapy in Pediatrics: Results from an International Pediatric Research Consortium

Sara Alcorn, Kristina Nilsson, Avani D. Rao, Matthew Ladra, Ralph P. Ermoian, Rosangela C. Villar, Michael J. Chen, Daria Kobyzeva, Alexey V. Nechesnyuk, Eric Ford, Shannon Macdonald, Brian Winey, Karin Dieckmann, Stephanie A Terezakis

Research output: Contribution to journalArticle

Abstract

Purpose/Objectives: There is little consensus regarding the application of stereotactic radiotherapy (SRT) in pediatrics. We evaluated patterns of pediatric SRT practice through an international research consortium. Materials and Methods: Eight international institutions with pediatric expertise completed a 124-item survey evaluating patterns of SRT use for patients 21 years old and younger. Frequencies of SRT use and median margins applied with and without SRT were evaluated. Results: Across institutions, 75% reported utilizing SRT in pediatrics. SRT was used in 22% of brain, 18% of spine, 16% of other bone, 16% of head and neck, and <1% of abdomen/pelvis, lung, and liver cases across sites. Of the hypofractionated SRT cases, 42% were delivered with definitive intent. Median gross tumor volume to planning target volume margins for SRT versus non-SRT plans were 0.2 versus 1.4 cm for brain, 0.3 versus 1.5 cm for spine/other bone, 0.3 versus 2.0 cm for abdomen/pelvis, 0.7 versus 1.5 cm for head and neck, 0.5 versus 1.7 cm for lung, and 0.5 versus 2.0 cm for liver sites. Conclusions: SRT is commonly utilized in pediatrics across a range of treatment sites. Margins used for SRT were substantially smaller than for non-SRT planning, highlighting the utility of this approach in reducing treatment volumes. ©

Original languageEnglish (US)
Pages (from-to)522-526
Number of pages5
JournalJournal of Pediatric Hematology/Oncology
Volume40
Issue number7
DOIs
StatePublished - Oct 1 2018

Fingerprint

Radiotherapy
Pediatrics
Research
Pelvis
Abdomen
Spine
Neck
Head
Bone and Bones
Lung
Liver
Brain
Tumor Burden
Therapeutics

Keywords

  • pediatric stereotactic radiosurgery
  • stereotactic body radiation therapy
  • stereotactic radiosurgery

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Practice Patterns of Stereotactic Radiotherapy in Pediatrics : Results from an International Pediatric Research Consortium. / Alcorn, Sara; Nilsson, Kristina; Rao, Avani D.; Ladra, Matthew; Ermoian, Ralph P.; Villar, Rosangela C.; Chen, Michael J.; Kobyzeva, Daria; Nechesnyuk, Alexey V.; Ford, Eric; Macdonald, Shannon; Winey, Brian; Dieckmann, Karin; Terezakis, Stephanie A.

In: Journal of Pediatric Hematology/Oncology, Vol. 40, No. 7, 01.10.2018, p. 522-526.

Research output: Contribution to journalArticle

Alcorn, S, Nilsson, K, Rao, AD, Ladra, M, Ermoian, RP, Villar, RC, Chen, MJ, Kobyzeva, D, Nechesnyuk, AV, Ford, E, Macdonald, S, Winey, B, Dieckmann, K & Terezakis, SA 2018, 'Practice Patterns of Stereotactic Radiotherapy in Pediatrics: Results from an International Pediatric Research Consortium', Journal of Pediatric Hematology/Oncology, vol. 40, no. 7, pp. 522-526. https://doi.org/10.1097/MPH.0000000000001290
Alcorn, Sara ; Nilsson, Kristina ; Rao, Avani D. ; Ladra, Matthew ; Ermoian, Ralph P. ; Villar, Rosangela C. ; Chen, Michael J. ; Kobyzeva, Daria ; Nechesnyuk, Alexey V. ; Ford, Eric ; Macdonald, Shannon ; Winey, Brian ; Dieckmann, Karin ; Terezakis, Stephanie A. / Practice Patterns of Stereotactic Radiotherapy in Pediatrics : Results from an International Pediatric Research Consortium. In: Journal of Pediatric Hematology/Oncology. 2018 ; Vol. 40, No. 7. pp. 522-526.
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AU - Ladra, Matthew

AU - Ermoian, Ralph P.

AU - Villar, Rosangela C.

AU - Chen, Michael J.

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AU - Ford, Eric

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