Practical combination therapy based on pathophysiology of type 2 diabetes

Research output: Contribution to journalArticlepeer-review

Abstract

Type 2 diabetes is a complex, chronic, and progressive condition that often necessitates the use of multiple medications to achieve glycemic goals. Clinical guidelines generally recommend intensifying pharmacotherapy if glycemic goals are not achieved after 3 months of treatment. However, for many patients with type 2 diabetes, treatment intensification is delayed or does not occur. Initiating combination therapy early in the disease course has the potential to delay disease progression and improve patient outcomes. Guidelines generally provide a list of agents that may be used in combination regimens and emphasize individualization of treatment. The purpose of this review is to discuss the rationale for combination therapy, considering treatment effects on pathophysiologic aspects of type 2 diabetes and individual drug profiles. The combination of newer antidiabetes therapies with complementary mechanisms of action provides the opportunity to target multiple sites of tissue, organ, and cellular dysfunction.

Original languageEnglish (US)
Pages (from-to)355-369
Number of pages15
JournalDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Volume9
DOIs
StatePublished - Oct 31 2016
Externally publishedYes

Keywords

  • Combination therapy
  • Insulin
  • Oral antidiabetes drugs
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Pharmacology

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