Practical aspects of in situ 16O (γ,n) 15O activation using a conventional medical accelerator for the purpose of perfusion imaging

M. Oldham, S. A. Sapareto, X. A. Li, J. Allen, S. Sutlief, O. C. Wong, John Wong

Research output: Contribution to journalArticle

Abstract

We report investigations into the feasibility of generating radioactive oxygen (15O, a positron emitter, with half-life 2.05 min) using a tuned Elekta SL25 accelerator, for the end purpose of imaging tumor perfusion. 15O is produced by the "gamma, neutron," (γ,n) reaction between high-energy photons and normal oxygen (16O) in the body. As most in vivo 16O is bound in water molecules the 15O radio-marker is produced in proportion to water content in tissue. Imaging the washout of the 15O distribution using sensitive positron-emission-tomography (PET) technology can yield spatial information about blood perfusion in the tissue. The aim of this article was to determine the amount of 15O activity that could be produced by the tuned medical accelerator. A further aim was to model the activation process using Monte Carlo and to investigate ways to optimize the amount of 15O that could be generated. Increased activation was achieved by (i) tuning the beam to give higher-energy electrons incident on the target of the accelerator, (ii) increasing dose rate by removing the conventional filtration in the beam and reducing the source to object distance, and (iii) reducing low-energy photons by means of a carbon block absorber. The activity per-unit-dose produced by the tuned beam was measured by irradiating spheres of water to known doses and placing the spheres in a calibrated coincidence-counting apparatus. Peak energy of the tuned bremsstrahlung beam was estimated at 29 MeV, and generated activity up to 0.24/μCi/cc/3Gy in water. The measured amount of 15O agreed to within 10% of the prediction from the Monte-Carlo-computed spectrum, indicating reasonable ability to model the activation process. The optimal thickness of the carbon absorber was found to be about 25 cm. The insertion of a carbon absorber improved spectral quality for activation purposes but at the cost of reduced dose rate. In conclusion, the viability of generating 15O with an Elekta SL25 has been demonstrated. In conjunction with recent advances in high-sensitivity portable PET imaging devices, real potential exists for imaging in situ activated 15O washout as a surrogate measurement of macroscopic tumor perfusion.

Original languageEnglish (US)
Pages (from-to)1669-1678
Number of pages10
JournalMedical Physics
Volume28
Issue number8
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Perfusion Imaging
Carbon
Water
Photons
Positron-Emission Tomography
Perfusion
Electrons
Oxygen
Neutrons
Radio
Half-Life
Neoplasms
Technology
Equipment and Supplies

Keywords

  • O activation
  • In situ
  • Perfusion imaging
  • Radiation therapy

ASJC Scopus subject areas

  • Biophysics

Cite this

Practical aspects of in situ 16O (γ,n) 15O activation using a conventional medical accelerator for the purpose of perfusion imaging. / Oldham, M.; Sapareto, S. A.; Li, X. A.; Allen, J.; Sutlief, S.; Wong, O. C.; Wong, John.

In: Medical Physics, Vol. 28, No. 8, 2001, p. 1669-1678.

Research output: Contribution to journalArticle

Oldham, M. ; Sapareto, S. A. ; Li, X. A. ; Allen, J. ; Sutlief, S. ; Wong, O. C. ; Wong, John. / Practical aspects of in situ 16O (γ,n) 15O activation using a conventional medical accelerator for the purpose of perfusion imaging. In: Medical Physics. 2001 ; Vol. 28, No. 8. pp. 1669-1678.
@article{83a605f82f5046ca8cec8536a1d2de61,
title = "Practical aspects of in situ 16O (γ,n) 15O activation using a conventional medical accelerator for the purpose of perfusion imaging",
abstract = "We report investigations into the feasibility of generating radioactive oxygen (15O, a positron emitter, with half-life 2.05 min) using a tuned Elekta SL25 accelerator, for the end purpose of imaging tumor perfusion. 15O is produced by the {"}gamma, neutron,{"} (γ,n) reaction between high-energy photons and normal oxygen (16O) in the body. As most in vivo 16O is bound in water molecules the 15O radio-marker is produced in proportion to water content in tissue. Imaging the washout of the 15O distribution using sensitive positron-emission-tomography (PET) technology can yield spatial information about blood perfusion in the tissue. The aim of this article was to determine the amount of 15O activity that could be produced by the tuned medical accelerator. A further aim was to model the activation process using Monte Carlo and to investigate ways to optimize the amount of 15O that could be generated. Increased activation was achieved by (i) tuning the beam to give higher-energy electrons incident on the target of the accelerator, (ii) increasing dose rate by removing the conventional filtration in the beam and reducing the source to object distance, and (iii) reducing low-energy photons by means of a carbon block absorber. The activity per-unit-dose produced by the tuned beam was measured by irradiating spheres of water to known doses and placing the spheres in a calibrated coincidence-counting apparatus. Peak energy of the tuned bremsstrahlung beam was estimated at 29 MeV, and generated activity up to 0.24/μCi/cc/3Gy in water. The measured amount of 15O agreed to within 10{\%} of the prediction from the Monte-Carlo-computed spectrum, indicating reasonable ability to model the activation process. The optimal thickness of the carbon absorber was found to be about 25 cm. The insertion of a carbon absorber improved spectral quality for activation purposes but at the cost of reduced dose rate. In conclusion, the viability of generating 15O with an Elekta SL25 has been demonstrated. In conjunction with recent advances in high-sensitivity portable PET imaging devices, real potential exists for imaging in situ activated 15O washout as a surrogate measurement of macroscopic tumor perfusion.",
keywords = "O activation, In situ, Perfusion imaging, Radiation therapy",
author = "M. Oldham and Sapareto, {S. A.} and Li, {X. A.} and J. Allen and S. Sutlief and Wong, {O. C.} and John Wong",
year = "2001",
doi = "10.1118/1.1386777",
language = "English (US)",
volume = "28",
pages = "1669--1678",
journal = "Medical Physics",
issn = "0094-2405",
publisher = "AAPM - American Association of Physicists in Medicine",
number = "8",

}

TY - JOUR

T1 - Practical aspects of in situ 16O (γ,n) 15O activation using a conventional medical accelerator for the purpose of perfusion imaging

AU - Oldham, M.

AU - Sapareto, S. A.

AU - Li, X. A.

AU - Allen, J.

AU - Sutlief, S.

AU - Wong, O. C.

AU - Wong, John

PY - 2001

Y1 - 2001

N2 - We report investigations into the feasibility of generating radioactive oxygen (15O, a positron emitter, with half-life 2.05 min) using a tuned Elekta SL25 accelerator, for the end purpose of imaging tumor perfusion. 15O is produced by the "gamma, neutron," (γ,n) reaction between high-energy photons and normal oxygen (16O) in the body. As most in vivo 16O is bound in water molecules the 15O radio-marker is produced in proportion to water content in tissue. Imaging the washout of the 15O distribution using sensitive positron-emission-tomography (PET) technology can yield spatial information about blood perfusion in the tissue. The aim of this article was to determine the amount of 15O activity that could be produced by the tuned medical accelerator. A further aim was to model the activation process using Monte Carlo and to investigate ways to optimize the amount of 15O that could be generated. Increased activation was achieved by (i) tuning the beam to give higher-energy electrons incident on the target of the accelerator, (ii) increasing dose rate by removing the conventional filtration in the beam and reducing the source to object distance, and (iii) reducing low-energy photons by means of a carbon block absorber. The activity per-unit-dose produced by the tuned beam was measured by irradiating spheres of water to known doses and placing the spheres in a calibrated coincidence-counting apparatus. Peak energy of the tuned bremsstrahlung beam was estimated at 29 MeV, and generated activity up to 0.24/μCi/cc/3Gy in water. The measured amount of 15O agreed to within 10% of the prediction from the Monte-Carlo-computed spectrum, indicating reasonable ability to model the activation process. The optimal thickness of the carbon absorber was found to be about 25 cm. The insertion of a carbon absorber improved spectral quality for activation purposes but at the cost of reduced dose rate. In conclusion, the viability of generating 15O with an Elekta SL25 has been demonstrated. In conjunction with recent advances in high-sensitivity portable PET imaging devices, real potential exists for imaging in situ activated 15O washout as a surrogate measurement of macroscopic tumor perfusion.

AB - We report investigations into the feasibility of generating radioactive oxygen (15O, a positron emitter, with half-life 2.05 min) using a tuned Elekta SL25 accelerator, for the end purpose of imaging tumor perfusion. 15O is produced by the "gamma, neutron," (γ,n) reaction between high-energy photons and normal oxygen (16O) in the body. As most in vivo 16O is bound in water molecules the 15O radio-marker is produced in proportion to water content in tissue. Imaging the washout of the 15O distribution using sensitive positron-emission-tomography (PET) technology can yield spatial information about blood perfusion in the tissue. The aim of this article was to determine the amount of 15O activity that could be produced by the tuned medical accelerator. A further aim was to model the activation process using Monte Carlo and to investigate ways to optimize the amount of 15O that could be generated. Increased activation was achieved by (i) tuning the beam to give higher-energy electrons incident on the target of the accelerator, (ii) increasing dose rate by removing the conventional filtration in the beam and reducing the source to object distance, and (iii) reducing low-energy photons by means of a carbon block absorber. The activity per-unit-dose produced by the tuned beam was measured by irradiating spheres of water to known doses and placing the spheres in a calibrated coincidence-counting apparatus. Peak energy of the tuned bremsstrahlung beam was estimated at 29 MeV, and generated activity up to 0.24/μCi/cc/3Gy in water. The measured amount of 15O agreed to within 10% of the prediction from the Monte-Carlo-computed spectrum, indicating reasonable ability to model the activation process. The optimal thickness of the carbon absorber was found to be about 25 cm. The insertion of a carbon absorber improved spectral quality for activation purposes but at the cost of reduced dose rate. In conclusion, the viability of generating 15O with an Elekta SL25 has been demonstrated. In conjunction with recent advances in high-sensitivity portable PET imaging devices, real potential exists for imaging in situ activated 15O washout as a surrogate measurement of macroscopic tumor perfusion.

KW - O activation

KW - In situ

KW - Perfusion imaging

KW - Radiation therapy

UR - http://www.scopus.com/inward/record.url?scp=0034857347&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034857347&partnerID=8YFLogxK

U2 - 10.1118/1.1386777

DO - 10.1118/1.1386777

M3 - Article

C2 - 11548936

AN - SCOPUS:0034857347

VL - 28

SP - 1669

EP - 1678

JO - Medical Physics

JF - Medical Physics

SN - 0094-2405

IS - 8

ER -