PPARγ in immunity and inflammation: cell types and diseases

Lajos Széles, Dániel Töröcsik, László Nagy

Research output: Contribution to journalReview articlepeer-review

Abstract

The lipid activated transcription factor, PPARγ appears to have multiple functions in the immune system. There are several cell types expressing the receptor, most prominently antigen presenting cells, such as macrophages and dendritic cells. The receptor's activation leads to primary transcriptional activation of many, mostly lipid metabolism-related genes. However, gene regulation also occurs on immunity and inflammation-related genes. Key questions are: in what way lipid metabolism and immune regulation are connected and how activation and/or repression of gene expression may modulate inflammatory and anti-inflammatory responses and in what way can these be utilized in therapy. Here we provide a cell type and disease centric review on the role of this lipid activated transcription factor in the various cells of the immune system it is expressed in, and in some major inflammatory diseases such as atherosclerosis, inflammatory bowel disease and rheumatoid arthritis.

Original languageEnglish (US)
Pages (from-to)1014-1030
Number of pages17
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume1771
Issue number8
DOIs
StatePublished - Aug 2007

Keywords

  • Atherosclerosis
  • Chronic inflammation
  • Dendritic cell
  • Inflammation
  • Inflammatory bowel disease
  • Macrophage
  • Peroxisome Proliferator-Activated Receptor gamma

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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