TY - GEN
T1 - PPARγ, a lipid-activated transcription factor as a regulator of dendritic cell function
AU - Szatmari, Istvan
AU - Rajnavolgyi, Eva
AU - Nagy, Laszlo
PY - 2006/11
Y1 - 2006/11
N2 - In recent years it became apparent that PPARγ, besides being a key component of adipose tissue development and a target of insulin-sensitizing drugs, also has a role in immune cell differentiation and function. This receptor has been identified by us and others as a conductor of lipid handling in macrophages, and has roles also in inflammation control. Here we review recent advances on the role of this nuclear receptor in another key cell type of myeloid origin, dendritic cells (DCs). DCs are professional antigen-presenting cells having essential roles in antigen-uptake processing and presentation and in initiation of various forms of immune responses. It appears that PPARγ is expressed and is active in myeloid DCs and likely to be a regulator of DC function by altering antigen uptake, maturation, activation, migration, cytokine production, and lipid antigen presentation. Thus PPARγ is at the crossroads of lipid metabolism and innate immune response, and by studying its functions one has a unique opportunity to discern how these two seemingly distant fields (lipid metabolism and immune response) are interrelated. It is also possible that this receptor is a relevant target for pharmacological intervention in immune diseases such as chronic inflammation and autoimmune conditions.
AB - In recent years it became apparent that PPARγ, besides being a key component of adipose tissue development and a target of insulin-sensitizing drugs, also has a role in immune cell differentiation and function. This receptor has been identified by us and others as a conductor of lipid handling in macrophages, and has roles also in inflammation control. Here we review recent advances on the role of this nuclear receptor in another key cell type of myeloid origin, dendritic cells (DCs). DCs are professional antigen-presenting cells having essential roles in antigen-uptake processing and presentation and in initiation of various forms of immune responses. It appears that PPARγ is expressed and is active in myeloid DCs and likely to be a regulator of DC function by altering antigen uptake, maturation, activation, migration, cytokine production, and lipid antigen presentation. Thus PPARγ is at the crossroads of lipid metabolism and innate immune response, and by studying its functions one has a unique opportunity to discern how these two seemingly distant fields (lipid metabolism and immune response) are interrelated. It is also possible that this receptor is a relevant target for pharmacological intervention in immune diseases such as chronic inflammation and autoimmune conditions.
KW - CD1
KW - Dendritic cells
KW - Innate immune response
KW - Lipid metabolism
KW - Nuclear hormone receptors
KW - PPARγ
KW - Transcription
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U2 - 10.1196/annals.1366.013
DO - 10.1196/annals.1366.013
M3 - Conference contribution
C2 - 17192567
AN - SCOPUS:34447627877
SN - 1573316237
SN - 9781573316231
T3 - Annals of the New York Academy of Sciences
SP - 207
EP - 218
BT - Neuroendocrine and Immune Crosstalk
PB - Blackwell Publishing Inc.
ER -