@article{f0fce79223174512ac89c554a98bfedf,
title = "PPARδ is an APC-regulated target of nonsteroidal anti-inflammatory drugs",
abstract = "PPARδ was identified as a target of APC through the analysis of global gene expression profiles in human colorectal cancer (CRC) cells. PPARδ expression was elevated in CRCs and repressed by APC in CRC cells. This repression was mediated by β-catenin/Tcf-4-responsive elements in the PPARδ promotor. The ability of PPARs to bind eicosanoids suggested that PPARδ might be a target of chemopreventive nonsteroidal anti-inflammatory drugs (NSAIDs). Reporters containing PPARS-responsive elements were repressed by the NSAID sulindac. Furthermore, sulindac was able to disrupt the ability of PPARδ to bind its recognition sequences. These findings suggest that NSAIDs inhibit tumorigenesis through inhibition of PPARδ, the gene for which is normally regulated by APC.",
author = "He, {Tong Chuan} and Chan, {Timothy A.} and Bert Vogelstein and Kinzler, {Kenneth W.}",
note = "Funding Information: We thank Carlo Rago, Christopher Torrance, Victor Velculescu, Leigh Zawel, Lin Zhang, and Wei Zhou for their help and advice and Heiko Hermeking for providing the AdMyc. This work is supported by National Institutes of Health grants CA57345 and CA62924. B. V. is an investigator of the Howard Hughes Medical Institute. K. W. K. received research funding from Genzyme Molecular Oncology (Genzyme). Under a licensing agreement between the Johns Hopkins University and Genzyme, the SAGE technology was licensed to Genzyme, and K. W. K. and B. V. are entitled to a share of royalties received by the University from sales of the licensed technology. The SAGE technology is freely available to academia for research purposes. K. W. K. and B. V. are consultants to Genzyme. The University and researchers (K. W. K. and B. V.) own Genzyme stock, which is subject to certain restrictions under University policy. The terms of this arrangement are being managed by the University in accordance with its conflict of interest policies.",
year = "1999",
month = oct,
day = "29",
doi = "10.1016/S0092-8674(00)81664-5",
language = "English (US)",
volume = "99",
pages = "335--345",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "3",
}