Powerful bactericidal and sterilizing activity of a regimen containing PA-824, moxifloxacin, and pyrazinamide in a murine model of tuberculosis

Eric Nuermberger, Sandeep Tyagi, Rokeya Tasneen, Kathy N. Williams, Deepak Almeida, Ian Rosenthal, Jacques H. Grosset

Research output: Contribution to journalArticle

Abstract

PA-824 is a nitroimidazo-oxazine in clinical testing for the treatment of tuberculosis. We report that the novel combination of PA-824, moxifloxacin, and pyrazinamide cured mice more rapidly than the first-line regimen of rifampin, isoniazid, and pyrazinamide. If applicable to humans, regimens containing this combination may radically shorten the treatment of multidrug-resistant tuberculosis.

Original languageEnglish (US)
Pages (from-to)1522-1524
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume52
Issue number4
DOIs
StatePublished - Apr 1 2008

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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