Potentiality of a new compound for in vitro differentiation between halophilic and non-halophilic vibrios

R. Ray, A. K. Das, N. K. Dutta, A. N. Chakrabarty, B. N. Chaudhuri, S. Seth, Sujata G. Dastidar

Research output: Contribution to journalArticlepeer-review

Abstract

Sensitivity of 21 halophilic vibrios and 16 clinical isolates of non-halophilic vibrios was determined against a new possible antivibrio agent, a pyrimidine analogue, 4, 6-dimethylpyrimidine -2-thiol (4,6-DMPT). It appeared to be a vibriocidal agent, having amean MIC and MBC of 32 μg/ml for halophilic strains and 64 μg/ml for non-halophilic strains and an LD50 of 300 mg/Kg body weight of mice. Thus, 4,6-DMPT may help an in vitro distinction between halophilic and non-halophilic vibrios. Sensitivity of these strains was also studied with respect to pteridine, crystal violet and Tween 80 hydrolysis as further markers distinguishing between these 2 groups which could also be differentiated by their growth on TCBS or/and CLED media.

Original languageEnglish (US)
Pages (from-to)220-222
Number of pages3
JournalIndian journal of experimental biology
Volume40
Issue number2
StatePublished - Feb 26 2002
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology
  • Cell Biology

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