Abstract
Sensitivity of 21 halophilic vibrios and 16 clinical isolates of non-halophilic vibrios was determined against a new possible antivibrio agent, a pyrimidine analogue, 4, 6-dimethylpyrimidine -2-thiol (4,6-DMPT). It appeared to be a vibriocidal agent, having amean MIC and MBC of 32 μg/ml for halophilic strains and 64 μg/ml for non-halophilic strains and an LD50 of 300 mg/Kg body weight of mice. Thus, 4,6-DMPT may help an in vitro distinction between halophilic and non-halophilic vibrios. Sensitivity of these strains was also studied with respect to pteridine, crystal violet and Tween 80 hydrolysis as further markers distinguishing between these 2 groups which could also be differentiated by their growth on TCBS or/and CLED media.
Original language | English (US) |
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Pages (from-to) | 220-222 |
Number of pages | 3 |
Journal | Indian journal of experimental biology |
Volume | 40 |
Issue number | 2 |
State | Published - 2002 |
Externally published | Yes |
ASJC Scopus subject areas
- Biotechnology
- Molecular Biology
- Cell Biology