Potential targeting of siglecs, mast cell inhibitory receptors, in interstitial cystitis

Chang Shin Park, Bruce S. Bochner

Research output: Contribution to journalReview article

Abstract

Mast cell increases and activation are detected in the chronic inflammatory bladder disease interstitial cystitis (IC), and their proinflammatory mediators are felt to contribute to regional pelvic pain and inflammatory pathophysiology. The immunoreceptor tyrosine-based inhibition motif-containing sialic acid-binding immunoglobulin-like lectins (Siglecs) expressed in mast cells could be evaluated as in vivo signaling regulators capable of inhibiting IC-related mast cell activation.

Original languageEnglish (US)
Pages (from-to)61-63
Number of pages3
JournalInternational Neurourology Journal
Volume15
Issue number2
DOIs
StatePublished - Jun 1 2011

Keywords

  • Interstitial cystitis
  • Mast cells
  • Sialic acid binding Ig-like lectin (Siglec)
  • Urinary bladder

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Urology

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