Potential role of stem cells for neuropathic pain disorders

Sudhakar Vadivelu, Matthew Willsey, Daniel J. Curry, John W. McDonald

Research output: Contribution to journalArticlepeer-review


Chronic neuropathic pain is a debilitating disease process associated with several medical disorders. Different from pain caused by inflammation, neuropathic pain is a diffuse pain disorder often found to be recalcitrant to the limited medical treatments available. Intractable nerve pain may benefit from other therapies capable of longer-lasting pain coverage or greater efficacy. A growing number of reports have emerged suggesting a role for stem cells as a cellular delivery source with neuroprotective agents opposing the effects of nerve damage. Here, the authors review the current experimental therapies examining the use of stem cells for the treatment of neuropathic pain disorders.

Original languageEnglish (US)
Article numberE11
JournalNeurosurgical focus
Issue number3
StatePublished - Sep 25 2013


  • Demyelination
  • Myelin
  • Nerve damage
  • Nerve growth factor
  • Neuropathy
  • Neurotrophic factor
  • Oligodendrocyte
  • Pain
  • Stem cell

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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