@article{1954ab55b6a44aa58780d005e272a822,
title = "Potential role of iron in repair of inflammatory demyelinating lesions",
abstract = "Inflammatory destruction of iron-rich myelin is characteristic of multiple sclerosis (MS). Although iron is needed for oligodendrocytes to produce myelin during development, its deposition has also been linked to neurodegeneration and inflammation, including in MS. We report perivascular iron deposition in multiple sclerosis lesions that was mirrored in 72 lesions from 13 marmosets with experimental autoimmune encephalomyelitis. Iron accumulated mainly inside microglia/ macrophages from 6 weeks after demyelination. Consistently, expression of transferrin receptor, the brain's main iron-influx protein, increased as lesions aged. Iron was uncorrelated with inflammation and postdated initial demyelination, suggesting that iron is not directly pathogenic. Iron homeostasis was at least partially restored in remyelinated, but not persistently demyelinated, lesions. Taken together, our results suggest that iron accumulation in the weeks after inflammatory demyelination may contribute to lesion repair rather than inflammatory demyelination per se.",
author = "Lee, {Nathanael J.} and Ha, {Seung Kwon} and Pascal Sati and Martina Absinta and Govind Nair and Luciano, {Nicholas J.} and Leibovitch, {Emily C.} and Yen, {Cecil C.} and Rouault, {Tracey A.} and Silva, {Afonso C.} and Steven Jacobson and Reich, {Daniel S.}",
note = "Funding Information: 1Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA. 2Department of Neuroscience, Georgetown University Medical Center, Georgetown University, Washington, District of Columbia, USA. 3Viral Immunology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA. 4Cerebral Microcirculation Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA. 5Section on Human Iron Metabolism, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA. Funding Information: We thank the National Institute of Neurological Disorders and Stroke (NINDS) Neuroimmunology Clinic and the NIH Functional Magnetic Resonance Imaging Facility for coordinating the acquisition of MRI scans, Mahin S. Hossain for helping with data analysis, and the NIH Medical Arts Branch for the artwork. We also thank Susan Cheng from the NINDS Elec tron Microscopy Facility for helping with tissue preparation and image acquisition. This research was supported by the Intramural Research Program of NINDS and the Adelson Medical Research Foundation. Publisher Copyright: {\textcopyright} 2019, American Society for Clinical Investigation.",
year = "2019",
month = oct,
day = "1",
doi = "10.1172/JCI126809",
language = "English (US)",
volume = "129",
pages = "4365--4376",
journal = "Journal of Clinical Investigation",
issn = "0021-9738",
publisher = "The American Society for Clinical Investigation",
number = "10",
}