Potential Role for STAT3 Inhibitors in Glioblastoma

Christopher Jackson, Jacob Ruzevick, Anubhav G. Amin, Michael Lim

Research output: Contribution to journalReview article

Abstract

Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor. Signal transducers and activators of transcription 3 (STAT3) is a transcription factor that translocates to the nucleus to modulate the expression of a variety of genes associated with cell survival, differentiation, proliferation, angiogenesis, and immune function. Several cancers induce constitutive STAT3 activation. Most studies have reported that STAT3 inhibition has antineoplastic activity; however, emerging evidence suggests that the role of STAT3 activity in GBM may be more nuanced than initially appreciated. The authors review the roles of STAT3 in GBM and discuss potential strategies for targeting STAT3.

Original languageEnglish (US)
Pages (from-to)379-389
Number of pages11
JournalNeurosurgery clinics of North America
Volume23
Issue number3
DOIs
StatePublished - Jul 1 2012

Keywords

  • Glioblastoma multiforme
  • Inhibitors
  • STAT3
  • Signal transducers and activators of transcription

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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