Potential Proteomic-Based Strategies for Understanding Laminitis: Predictions and Pathogenesis

Research output: Contribution to journalArticle

Abstract

With today's understanding of the genome, advanced molecular techniques, and our growing ability to analyze complex biologic data, proteomics, the broad-based study of the repertoire of proteins expressed by cells or organisms, offers great promise for understanding the causes of complex diseases. Identifying and measuring novel protein biomarkers present in blood that predict the onset and resolution of laminitis would both aid clinical management of at-risk equine patients and shed light on underlying mechanisms with the intent of developing novel preventive strategies and therapeutic approaches. Identifying alterations in the profiles of proteins present in tissues of horses that develop laminitis or within in vitro model systems also can advance our understanding of this puzzling disease.

Original languageEnglish (US)
Pages (from-to)484-487
Number of pages4
JournalJournal of Equine Veterinary Science
Volume28
Issue number8
DOIs
StatePublished - Aug 2008

Fingerprint

laminitis
Proteomics
proteomics
pathogenesis
Horses
prediction
horses
Proteins
proteins
Risk Management
biomarkers
Biomarkers
Genome
therapeutics
genome
blood
organisms
cells
Therapeutics
methodology

Keywords

  • Biomarkers
  • Equine
  • Laminitis
  • Pathogenesis
  • Proteomics

ASJC Scopus subject areas

  • veterinary(all)

Cite this

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abstract = "With today's understanding of the genome, advanced molecular techniques, and our growing ability to analyze complex biologic data, proteomics, the broad-based study of the repertoire of proteins expressed by cells or organisms, offers great promise for understanding the causes of complex diseases. Identifying and measuring novel protein biomarkers present in blood that predict the onset and resolution of laminitis would both aid clinical management of at-risk equine patients and shed light on underlying mechanisms with the intent of developing novel preventive strategies and therapeutic approaches. Identifying alterations in the profiles of proteins present in tissues of horses that develop laminitis or within in vitro model systems also can advance our understanding of this puzzling disease.",
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AB - With today's understanding of the genome, advanced molecular techniques, and our growing ability to analyze complex biologic data, proteomics, the broad-based study of the repertoire of proteins expressed by cells or organisms, offers great promise for understanding the causes of complex diseases. Identifying and measuring novel protein biomarkers present in blood that predict the onset and resolution of laminitis would both aid clinical management of at-risk equine patients and shed light on underlying mechanisms with the intent of developing novel preventive strategies and therapeutic approaches. Identifying alterations in the profiles of proteins present in tissues of horses that develop laminitis or within in vitro model systems also can advance our understanding of this puzzling disease.

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