Potential opportunities and perils of imperfect dengue vaccines

Isabel Rodriguez-Barraquer, Luis Mier-y-Teran-Romero, Ira B. Schwartz, Donald S. Burke, Derek A.T. Cummings

Research output: Contribution to journalArticlepeer-review

Abstract

Dengue vaccine development efforts have focused on the development of tetravalent vaccines. However, a recent Phase IIb trial of a tetravalent vaccine indicates a protective effect against only 3 of the 4 serotypes. While vaccines effective against a subset of serotypes may reduce morbidity and mortality, particular profiles could result in an increased number of cases due to immune enhancement and other peculiarities of dengue epidemiology. Here, we use a compartmental transmission model to assess the impact of partially effective vaccines in a hyperendemic Thai population. Crucially, we evaluate the effects that certain serotype heterogeneities may have in the presence of mass-vaccination campaigns.In the majority of scenarios explored, partially effective vaccines lead to 50% or greater reductions in the number of cases. This is true even of vaccines that we would not expect to proceed to licensure due to poor or incomplete immune responses. Our results show that a partially effective vaccine can have significant impacts on serotype distribution and mean age of cases.

Original languageEnglish (US)
Pages (from-to)514-520
Number of pages7
JournalVaccine
Volume32
Issue number4
DOIs
StatePublished - Jan 16 2014

Keywords

  • Dengue vaccine
  • Mathematical model
  • Vaccine effects

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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