Potential of protein kinase inhibitors for treating herpesvirus-associated disease

Renfeng Li, S. Diane Hayward

Research output: Contribution to journalReview article

Abstract

Herpesviruses are ubiquitous human pathogens that establish lifelong persistent infections. Clinical manifestations range from mild self-limiting outbreaks such as childhood rashes and cold sores to the more severe and life-threatening outcomes of disseminated infection, encephalitis, and cancer. Nucleoside analog drugs that target viral DNA replication provide the primary means of treatment. However, extended use of these drugs can result in selection for drug-resistant strains, particularly in immunocompromised patients. In this review we will present recent observations about the participation of cellular protein kinases in herpesvirus biology and discuss the potential for targeting these protein kinases as well as the herpesvirus-encoded protein kinases as an anti-herpesvirus therapeutic strategy.

Original languageEnglish (US)
Pages (from-to)286-295
Number of pages10
JournalTrends in Microbiology
Volume21
Issue number6
DOIs
StatePublished - Jun 2013

Keywords

  • Antiviral drug development
  • Herpesvirus
  • Phosphorylation
  • Protein kinase
  • Protein kinase inhibitor

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

Fingerprint Dive into the research topics of 'Potential of protein kinase inhibitors for treating herpesvirus-associated disease'. Together they form a unique fingerprint.

  • Cite this