Potential methods to circumvent blocks in apoptosis in lymphomas

Research output: Contribution to journalReview article

Abstract

We review our current understanding of the molecular determinants and mechanisms of lymphocyte apoptosis and identify the key regulators of these death-signaling pathways. In addition, we describe the key molecular aberrations that underlie the resistance of lymphomas to conventional therapy, and highlight the enormous promise of potential therapeutic strategies that could circumvent or overcome these genetic impediments to apoptosis.

Original languageEnglish (US)
Pages (from-to)490-503
Number of pages14
JournalCurrent opinion in oncology
Volume14
Issue number5
DOIs
StatePublished - Sep 1 2002

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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