Potential mechanisms for the association between fall birth and food allergy

C. A. Keet, E. C. Matsui, J. H. Savage, D. L. Neuman-Sunshine, J. Skripak, R. D. Peng, R. A. Wood

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Background Season of birth has been reported as a risk factor for food allergy, but the mechanisms by which it acts are unknown. Methods Two populations were studied: 5862 children from the National Health and Nutrition Examination Survey (NHANES) III and 1514 well-characterized food allergic children from the Johns Hopkins Pediatric Allergy Clinic (JHPAC). Food allergy was defined as self-report of an acute reaction to a food (NHANES), or as milk, egg, and peanut allergy. Logistic regression compared fall or nonfall birth between (i) food allergic and nonallergic subjects in NHANES, adjusted for ethnicity, age, income, and sex, and (ii) JHPAC subjects and the general Maryland population. For NHANES, stratification by ethnicity and for JHPAC, eczema were examined. Results Fall birth was more common among food allergic subjects in both NHANES (OR, 1.91; 95% CI, 1.31-2.77) and JHPAC/Maryland (OR, 1.31; 95% CI, 1.18-1.47). Ethnicity interacted with season (OR, 2.34; 95% CI, 1.43-3.82 for Caucasians; OR, 1.19; 95% CI, 0.77-1.86 for non-Caucasians; P = 0.04 for interaction), as did eczema (OR, 1.47; 95% CI, 1.29-1.67 with eczema; OR, 1.00; 95% CI, 0.80-1.23 without eczema; P = 0.002 for interaction). Conclusions Fall birth is associated with increased risk of food allergy, and this risk is greatest among those most likely to have seasonal variation in vitamin D during infancy (Caucasians) and those at risk for skin barrier dysfunction (subjects with a history of eczema), suggesting that vitamin D and the skin barrier may be implicated in seasonal associations with food allergy.

Original languageEnglish (US)
Pages (from-to)775-782
Number of pages8
JournalAllergy: European Journal of Allergy and Clinical Immunology
Issue number6
StatePublished - Jun 2012


  • eczema
  • food allergy
  • season of birth
  • vitamin D

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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