Potential management of resistant microbial infections with a novel non-antibiotic: the anti-inflammatory drug diclofenac sodium

Noton Kumar Dutta, Subramanian Annadurai, Kaushiki Mazumdar, Sujata G. Dastidar, Jette E. Kristiansen, Joseph Molnar, Marta Martins, Leonard Amaral

Research output: Contribution to journalArticlepeer-review

Abstract

Diclofenac sodium (Dc), an anti-inflammatory agent, has remarkable inhibitory action both against drug-sensitive and drug-resistant clinical isolates of various Gram-positive and Gram-negative bacteria. The aim of this study was to determine the ability of Dc to protect mice from a virulent Salmonella infection. Dc injected at 1.5 μg/g and 3.0 μg/g mouse body weight significantly protected animals from the lethality of Salmonella infection. As was the case for the in vitro interaction, Dc in combination with streptomycin was even more effective. The non-antibiotic drug Dc has potential for the management of problematic antibiotic-resistant bacterial infections.

Original languageEnglish (US)
Pages (from-to)242-249
Number of pages8
JournalInternational Journal of Antimicrobial Agents
Volume30
Issue number3
DOIs
StatePublished - Sep 2007

Keywords

  • Antimicrobial activity
  • Diclofenac
  • In vitro
  • In vivo
  • Non-antibiotics
  • Resistant microbial infections

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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