@article{67eda1f97ab946b98202186f2277fb3c,
title = "Potential interaction between timing of infant complementary feeding and breastfeeding duration in determination of early childhood gut microbiota composition and BMI",
abstract = "Background: Introducing complementary foods other than breastmilk or formula acutely changes the infant gut microbiota composition. However, it is unknown whether the timing of introduction to complementary foods (early vs. late) in infancy is associated with early childhood gut microbiota and BMI, and if these associations depend on breastfeeding duration. Objective: Our primary objective was to investigate whether timing of infant complentary feeding with solid foods is associated with early childhood gut microbiota composition and BMI-z, and whether these associations differ by duration of breastfeeding. Methods: We used data from a Canadian pre-birth cohort followed till age 5 years. We examined timing of introduction to solid foods with the gut microbiota, determined by 16S rRNA gene sequencing of stool collected at 5 years of age, and age-and-sex specific BMI-z. We conducted analyses before and after stratifying by breastfeeding duration, and adjusted for delivery mode, gestational age and birth weight. Results: Of the 392 children in the analysis, 109 (27.8%) had early (≤4 months) solids. The association between early (vs later) solids and BMI-z at 5 years was modified by breastfeeding status at 4 months (P =.06). Among children breastfed >4 months, early (vs later) solids were associated with differential relative abundance of 6 bacterial taxa, including lower Roseburia, and 0.30 higher BMI-z (95% CI: 0.05, 0.55) at 5 years. In children breastfed <4 months, early solids were associated with differential relative abundance of 9 taxa, but not with child BMI-z. Conclusions: Early (vs. later) introduction to solid foods in infancy is associated with altered gut microbiota composition and BMI in early childhood, however these associations differ by duration of breastfeeding.",
keywords = "childhood weight, complementary feeding, microbiome, obesity, paediatrics",
author = "Differding, {Moira K.} and Myriam Doyon and Luigi Bouchard and Patrice Perron and Ren{\'e}e Gu{\'e}rin and Claude Asselin and Eric Mass{\'e} and Hivert, {Marie France} and Mueller, {Noel T.}",
note = "Funding Information: American Diabetes Association, Grant/Award Number: 1‐15‐ACE‐26; Canadian Institutes of Health Research, Grant/Award Numbers: 152989, MOP69005; Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke; Fonds de Recherche du Qu{\'e}bec ‐ Sant{\'e}; Merck; Mid‐Atlantic Nutrition Obesity Research Center (NORC), Grant/Award Number: P30DK072488; National Heart, Lung, and Blood Institute, Grant/Award Number: K01HL141589 Funding information Funding Information: Dr. Mueller was supported by the National Heart, Lung, And Blood Institute of the National Institutes of Health under Award Number K01HL141589 (PI: Mueller). Work in E Mass? Lab has been supported by grants from the Canadian Institutes of Health Research (CIHR) MOP69005, MERCK and the Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CRCHUS). The recruitment at 5 years has been supported by a grant from the CIHR (PJT 152989; PI: L Bouchard). The stool collection and analysis by a Pilot and Feasibility Grant from the Mid-Atlantic Nutrition Obesity Research Center (NORC) under NIH award number P30DK072488 and a Structuring Grant from the CRCHUS (PI: L Bouchard). Dr. Hivert is supported by an ADA Pathways to Stop Diabetes Early Investigator Award [1-15-ACE-26]. LB is a junior research scholar from the Fonds de la recherche du Qu?bec en sant? (FRQS). LB, EM, PP and CA are members of the FRQS-funded CRCHUS. Funding Information: Dr. Mueller was supported by the National Heart, Lung, And Blood Institute of the National Institutes of Health under Award Number K01HL141589 (PI: Mueller). Work in E Mass{\'e} Lab has been supported by grants from the Canadian Institutes of Health Research (CIHR) MOP69005, MERCK and the Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CRCHUS). The recruitment at 5 years has been supported by a grant from the CIHR (PJT 152989; PI: L Bouchard). The stool collection and analysis by a Pilot and Feasibility Grant from the Mid‐Atlantic Nutrition Obesity Research Center (NORC) under NIH award number P30DK072488 and a Structuring Grant from the CRCHUS (PI: L Bouchard). Dr. Hivert is supported by an ADA Pathways to Stop Diabetes Early Investigator Award [1‐15‐ACE‐26]. LB is a junior research scholar from the Fonds de la recherche du Qu{\'e}bec en sant{\'e} (FRQS). LB, EM, PP and CA are members of the FRQS‐funded CRCHUS. Publisher Copyright: {\textcopyright} 2020 World Obesity Federation",
year = "2020",
month = aug,
day = "1",
doi = "10.1111/ijpo.12642",
language = "English (US)",
volume = "15",
journal = "Pediatric obesity",
issn = "2047-6310",
publisher = "Wiley-Blackwell for the International Association for the Study of Obesity",
number = "8",
}