Potential hormonal and neurochemical biomarkers for postpartum depression

Liisa Hantsoo

doi:10.1016/B978-0-12-815508-0.00004-7

Potential hormonal and neurochemical biomarkers for postpartum depression

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Postpartum depression (PPD) affects approximately 10% of women worldwide. However, reliable biomarkers for PPD have not been established. Given the profound hormonal changes that occur perinatally, much of the research on biological underpinnings of PPD has focused on ovarian steroid hormones such as estradiol and progesterone. While hormonal factors likely play an important role in PPD etiology, there are likely other biological contributing factors. In this chapter, we review clinical evidence for potential biomarkers of PPD, including steroid hormones, hypothalamic-pituitary-adrenal axis hormones, monoamines, immune factors, and genetic and epigenetic factors.

Original language	English (US)
Title of host publication	Biomarkers of Postpartum Psychiatric Disorders
Publisher	Elsevier
Pages	45-63
Number of pages	19
ISBN (Electronic)	9780128155080
DOIs	https://doi.org/10.1016/B978-0-12-815508-0.00004-7
State	Published - Jan 1 2019
Externally published	Yes

Keywords

Estrogen
Hypothalamic-pituitary-adrenal (hpa) axis
Monoamines
Neuroactive steroids
Postpartum depression
Progesterone
Psychoneuroendocrinology
Psychoneuroimmunology
Serotonin

ASJC Scopus subject areas

General Psychology

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10.1016/B978-0-12-815508-0.00004-7

Cite this

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abstract = "Postpartum depression (PPD) affects approximately 10% of women worldwide. However, reliable biomarkers for PPD have not been established. Given the profound hormonal changes that occur perinatally, much of the research on biological underpinnings of PPD has focused on ovarian steroid hormones such as estradiol and progesterone. While hormonal factors likely play an important role in PPD etiology, there are likely other biological contributing factors. In this chapter, we review clinical evidence for potential biomarkers of PPD, including steroid hormones, hypothalamic-pituitary-adrenal axis hormones, monoamines, immune factors, and genetic and epigenetic factors.",

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AB - Postpartum depression (PPD) affects approximately 10% of women worldwide. However, reliable biomarkers for PPD have not been established. Given the profound hormonal changes that occur perinatally, much of the research on biological underpinnings of PPD has focused on ovarian steroid hormones such as estradiol and progesterone. While hormonal factors likely play an important role in PPD etiology, there are likely other biological contributing factors. In this chapter, we review clinical evidence for potential biomarkers of PPD, including steroid hormones, hypothalamic-pituitary-adrenal axis hormones, monoamines, immune factors, and genetic and epigenetic factors.

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KW - Psychoneuroimmunology

KW - Serotonin

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ER -

Potential hormonal and neurochemical biomarkers for postpartum depression

Abstract

Keywords

ASJC Scopus subject areas

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