Potential hormonal and neurochemical biomarkers for postpartum depression

Research output: Chapter in Book/Report/Conference proceedingChapter


Postpartum depression (PPD) affects approximately 10% of women worldwide. However, reliable biomarkers for PPD have not been established. Given the profound hormonal changes that occur perinatally, much of the research on biological underpinnings of PPD has focused on ovarian steroid hormones such as estradiol and progesterone. While hormonal factors likely play an important role in PPD etiology, there are likely other biological contributing factors. In this chapter, we review clinical evidence for potential biomarkers of PPD, including steroid hormones, hypothalamic-pituitary-adrenal axis hormones, monoamines, immune factors, and genetic and epigenetic factors.

Original languageEnglish (US)
Title of host publicationBiomarkers of Postpartum Psychiatric Disorders
Number of pages19
ISBN (Electronic)9780128155080
StatePublished - Jan 1 2019
Externally publishedYes


  • Estrogen
  • Hypothalamic-pituitary-adrenal (hpa) axis
  • Monoamines
  • Neuroactive steroids
  • Postpartum depression
  • Progesterone
  • Psychoneuroendocrinology
  • Psychoneuroimmunology
  • Serotonin

ASJC Scopus subject areas

  • Psychology(all)


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