Potential Antileprotic Agents. 1. Inhibition of a Model Mycobacterial System by Diaryl Sulfones

W. T. Colwell; G. Chan; V. H. Brown; J. I. DeGraw; J. H. Peters; N. E. Morrison

doi:10.1021/jm00247a031

Potential Antileprotic Agents. 1. Inhibition of a Model Mycobacterial System by Diaryl Sulfones

W. T. Colwell, G. Chan, V. H. Brown, J. I. DeGraw, J. H. Peters, N. E. Morrison

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22 Scopus citations

Abstract

The development of a new antileprotic agent poses particular problems in view of the fact that the etilogic agent of human leprosy, Mycobacterium, leprae, cannot be cultured in bacteriologic media. However, a correlation has been observed between minimum inhibitory concentrations (MIC) for Mycobacterium species 607, determined in vitro, and dietary MIC's for M. leprae growing in the mouse footpad 1,2 Clinical therapeutic practice in the treatment of leprosy is largely dependent on the use of 4,4′-diaminodiphenyl sulfone (DDS)³ or hydrolyzable derivatives.⁴ In an effort to establish the structure-activity requirements of diaryl sulfones relative to our mycobacterial model system we have prepared a series of DDS analogs and evaluated them as growth inhibitors of M. sp. 607.

Original language	English (US)
Pages (from-to)	142-144
Number of pages	3
Journal	Journal of medicinal chemistry
Volume	17
Issue number	1
DOIs	https://doi.org/10.1021/jm00247a031
State	Published - Jan 1 1974
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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title = "Potential Antileprotic Agents. 1. Inhibition of a Model Mycobacterial System by Diaryl Sulfones",

abstract = "The development of a new antileprotic agent poses particular problems in view of the fact that the etilogic agent of human leprosy, Mycobacterium, leprae, cannot be cultured in bacteriologic media. However, a correlation has been observed between minimum inhibitory concentrations (MIC) for Mycobacterium species 607, determined in vitro, and dietary MIC's for M. leprae growing in the mouse footpad 1,2 Clinical therapeutic practice in the treatment of leprosy is largely dependent on the use of 4,4′-diaminodiphenyl sulfone (DDS)3 or hydrolyzable derivatives.4 In an effort to establish the structure-activity requirements of diaryl sulfones relative to our mycobacterial model system we have prepared a series of DDS analogs and evaluated them as growth inhibitors of M. sp. 607.",

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AU - Chan, G.

AU - Brown, V. H.

AU - DeGraw, J. I.

AU - Peters, J. H.

AU - Morrison, N. E.

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AB - The development of a new antileprotic agent poses particular problems in view of the fact that the etilogic agent of human leprosy, Mycobacterium, leprae, cannot be cultured in bacteriologic media. However, a correlation has been observed between minimum inhibitory concentrations (MIC) for Mycobacterium species 607, determined in vitro, and dietary MIC's for M. leprae growing in the mouse footpad 1,2 Clinical therapeutic practice in the treatment of leprosy is largely dependent on the use of 4,4′-diaminodiphenyl sulfone (DDS)3 or hydrolyzable derivatives.4 In an effort to establish the structure-activity requirements of diaryl sulfones relative to our mycobacterial model system we have prepared a series of DDS analogs and evaluated them as growth inhibitors of M. sp. 607.

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Potential Antileprotic Agents. 1. Inhibition of a Model Mycobacterial System by Diaryl Sulfones

Abstract

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