Potential Antileprotic Agents. 1. Inhibition of a Model Mycobacterial System by Diaryl Sulfones

W. T. Colwell, G. Chan, V. H. Brown, J. I. DeGraw, J. H. Peters, N. E. Morrison

Research output: Contribution to journalArticle

Abstract

The development of a new antileprotic agent poses particular problems in view of the fact that the etilogic agent of human leprosy, Mycobacterium, leprae, cannot be cultured in bacteriologic media. However, a correlation has been observed between minimum inhibitory concentrations (MIC) for Mycobacterium species 607, determined in vitro, and dietary MIC's for M. leprae growing in the mouse footpad 1,2 Clinical therapeutic practice in the treatment of leprosy is largely dependent on the use of 4,4′-diaminodiphenyl sulfone (DDS)3 or hydrolyzable derivatives.4 In an effort to establish the structure-activity requirements of diaryl sulfones relative to our mycobacterial model system we have prepared a series of DDS analogs and evaluated them as growth inhibitors of M. sp. 607.

Original languageEnglish (US)
Pages (from-to)142-144
Number of pages3
JournalJournal of medicinal chemistry
Volume17
Issue number1
DOIs
StatePublished - Jan 1 1974

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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    Colwell, W. T., Chan, G., Brown, V. H., DeGraw, J. I., Peters, J. H., & Morrison, N. E. (1974). Potential Antileprotic Agents. 1. Inhibition of a Model Mycobacterial System by Diaryl Sulfones. Journal of medicinal chemistry, 17(1), 142-144. https://doi.org/10.1021/jm00247a031