Potent, low-calcemic, selective inhibitors of CYP24 hydroxylase: 24-Sulfone analogs of the hormone 1α,25-dihydroxyvitamin D3

Gary H. Posner, Kenneth R. Crawford, Hong Woon Yang, Mehmet Kahraman, Heung Bae Jeon, Hongbin Li, Jae Kyoo Lee, Byung Chul Suh, Mark A. Hatcher, Tanzina Labonte, Aimee Usera, Patrick M. Dolan, Thomas W. Kensler, Sara Peleg, Glenville Jones, Anqi Zhang, Bozena Korczak, Uttam Saha, Samuel S. Chuang

Research output: Contribution to journalArticle

Abstract

The new 24-phenylsulfone 4a, a low-calcemic analog of the natural hormone 1α,25-dihydroxyvitamin D3, is a potent (IC50 = 28 nM) and highly selective inhibitor of the human 24-hydroxylase enzyme CYP24.

Original languageEnglish (US)
Pages (from-to)5-12
Number of pages8
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume89-90
DOIs
StatePublished - May 2004

Keywords

  • Catabolism inhibitor
  • Low-calcemic
  • Vitamin D analogs

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Endocrinology
  • Clinical Biochemistry
  • Cell Biology

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  • Cite this

    Posner, G. H., Crawford, K. R., Yang, H. W., Kahraman, M., Jeon, H. B., Li, H., Lee, J. K., Suh, B. C., Hatcher, M. A., Labonte, T., Usera, A., Dolan, P. M., Kensler, T. W., Peleg, S., Jones, G., Zhang, A., Korczak, B., Saha, U., & Chuang, S. S. (2004). Potent, low-calcemic, selective inhibitors of CYP24 hydroxylase: 24-Sulfone analogs of the hormone 1α,25-dihydroxyvitamin D3. Journal of Steroid Biochemistry and Molecular Biology, 89-90, 5-12. https://doi.org/10.1016/j.jsbmb.2004.03.044