Potent inhibition of thyroid cancer cells by the MEK inhibitor PD0325901 and its potentiation by suppression of the PI3K and NF-κB pathways

Medicine & Life Sciences

• PD 0325901 100%
• Mitogen-Activated Protein Kinase Kinases 62%
• Phosphatidylinositol 3-Kinase 58%
• Thyroid Neoplasms 58%
• 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide 25%
• Genotype 10%
• Cell Cycle Resting Phase 8%
• MAP Kinase Signaling System 7%
• G1 Phase 7%
• Cell Cycle 5%
• Phosphotransferases 5%
• Alleles 5%
• Cell Proliferation 4%
• Cell Line 4%
• Mutation 4%
• Growth 3%
• Therapeutics 1%