Potent antibody-mediated neutralization limits bacteriophage treatment of a pulmonary Mycobacterium abscessus infection

Rebekah M. Dedrick, Krista G. Freeman, Jan A. Nguyen, Asli Bahadirli-Talbott, Bailey E. Smith, Andrew E. Wu, Aaron S. Ong, Cheng Ting Lin, Lisa C. Ruppel, Nicole M. Parrish, Graham F. Hatfull, Keira A. Cohen

Research output: Contribution to journalArticlepeer-review

Abstract

An 81-year-old immunocompetent patient with bronchiectasis and refractory Mycobacterium abscessus lung disease was treated for 6 months with a three-phage cocktail active against the strain. In this case study of phage to lower infectious burden, intravenous administration was safe and reduced the M. abscessus sputum load tenfold within one month. However, after two months, M. abscessus counts increased as the patient mounted a robust IgM- and IgG-mediated neutralizing antibody response to the phages, which was associated with limited therapeutic efficacy.

Original languageEnglish (US)
Pages (from-to)1357-1361
Number of pages5
JournalNature medicine
Volume27
Issue number8
DOIs
StatePublished - Aug 2021

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint

Dive into the research topics of 'Potent antibody-mediated neutralization limits bacteriophage treatment of a pulmonary Mycobacterium abscessus infection'. Together they form a unique fingerprint.

Cite this