TY - JOUR
T1 - Potato consumption does not increase blood pressure or incident hypertension in 2 cohorts of Spanish adults
AU - for the PREDIMED Study and SUN Project Investigators
AU - Hu, Emily A.
AU - Martínez-González, Miguel A.
AU - Salas-Salvadó, Jordi
AU - Corella, Dolores
AU - Ros, Emilio
AU - Fitó, Montse
AU - Garcia-Rodriguez, Antonio
AU - Estruch, Ramon
AU - Arós, Fernando
AU - Fiol, Miquel
AU - Lapetra, José
AU - Serra-Majem, Lluís
AU - Pintó, Xavier
AU - Ruiz-Canela, Miguel
AU - Razquin, Cristina
AU - Bulló, Mónica
AU - Sorlí, José V.
AU - Schröder, Helmut
AU - Rebholz, Casey M.
AU - Toledo, Estefania
AU - Bes-Rastrollo, M.
AU - De la Fuente-Arrillaga, C.
AU - Gea, A.
AU - Vázquez-Ruiz, Z.
AU - Rico, A.
AU - Núñez-Córdoba, J. M.
AU - Zazpe, I.
AU - Fernández-Montero, A.
AU - Pérez-de-Ciriza, P.
AU - Sánchez-Ruiz, D.
AU - Buil-Cosiales, P.
AU - Díez-Espino, J.
AU - Sanjulian, B.
AU - Marti, A.
AU - Martínez, J. A.
AU - Serrano-Martínez, M.
AU - Sánchez-Tainta, A.
AU - García-Arellano, A.
AU - Basteara-Gortari, J.
AU - Extremera-Urabayen, J. V.
AU - Garcia-Pérez, L.
AU - Arroyo-Azpa, C.
AU - Sola-Larraza, A.
AU - Barcena, F.
AU - Oreja-Arrayago, C.
AU - Lasanta-Sáez, M. J.
AU - Cia-Lecumberri, P.
AU - Elcarte-Lopez, T.
AU - Artal-Moneva, F.
AU - Esparza-López, J. M.
N1 - Funding Information:
Catalunya, Spain; grants from Bicentury SA, Spain; grants from Grand Fountaine, Spain; grants from Novartis SA, Spain; personal fees from Brewers of Europe, Belgium; personal fees from Fundacional Cerveza y Salud, Spain; personal fees from FIVIN, Spain; personal fees from Instituto Cervantes, Alburquerque, NM; personal fees from Instituto Cervantes, Milan, Italy; personal fees from Lilly Laboratories; personal fees from Prodeca: Generalitate de Catalunya; personal fees from Wine and Culinary International International Forum; Harvard School of Public Health, Boston, MA; and University of Columbia, NYC, outside the submitted work. ER reports grants, nonfinancial and other support from California Walnut Commission; grants, personal fees, nonfinancial and other support from Merck, Sharp & Dohme; grants, personal fees, nonfinancial and other support from Alexion; personal fees, nonfinancial and other support from Aegerion; grants and personal fees from Sanofi Aventis; grants, personal fees, nonfinancial and other support from Ferrer International; grants from Amgen; grants from Pfizer; and personal fees from Akcea, outside the submitted work. The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript. Supplemental Figures 1–3 and Supplemental Tables 1–5 are available from the ‘‘Online Supporting Material’’ link in the online posting of the article and from the same link in the online table of contents at http://jn.nutrition.org. Address correspondence to MAM-G (e-mail: mamartinez@unav.es). Abbreviations used: BP, blood pressure; CVD, cardiovascular disease; ICC, intraclass correlation coefficient; MedDiet, Mediterranean diet; PREDIMED, PREvención con DIeta MEDiterránea; SUN, Seguimiento Universidad de Navarra.
Funding Information:
Supported by the official funding agency for biomedical research of the Spanish Government, Instituto de Salud Carlos III through grants provided to research networks specifically developed for the trial (RTIC G03/140, to RE; RTIC RD 06/0045, to MAM-G) and through Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), and by grants from Centro Nacional de Investigaciones Cardiovasculares (CNIC 06/2007), Fondo de Investigación Sanitaria–Fondo Europeo de Desarrollo Regional [Proyecto de Investigación (PI) 04-2239, PI 05/2584, CP06/00100, PI07/0240, PI07/1138, PI07/0954, PI 07/0473, PI10/01407, PI10/02658, PI11/01647, P11/02505 and PI13/00462], Ministerio de Ciencia e Innovación [Recursos y teconologia agroalimentarias (AGL)-2009-13906-C02 and AGL2010-22319-C03 and AGL2013-49083-C3-1-R], Fundación Mapfre 2010, the Consejería de Salud de la Junta de Andalucía (PI0105/2007), the Public Health Division of the Department of Health of the Autonomous Government of Catalonia, Generalitat Valenciana [Generalitat Valenciana Ayuda Complementaria (GVACOMP) 06109, GVACOMP2010-181, GVACOMP2011-151], Conselleria de Sanitat y AP; Atención Primaria (CS) 2010-AP-111 and CS2011-AP-042, and Regional Government of Navarra (P27/2011). Author disclosures: EAH, MAM-G, JS-S, DC, M Fitó, AG-R, FA, M Fiol, JL, LS-M, XP, MR-C, CR, MB, JVS, HS, CMR, and ET, no conflicts of interest. RE reports grants from Spanish Institute of Health ‘‘Carlos III’’; Patrimonio Comunal Olivarero, Spain; California Walnut Commission; Borges SA, Spain; FIS, Government of Spain; Fundacion Bosch i Gimpera, Spain, during the conduct of the study; nonfinancial support from Cerveza y Salud, Spain; nonfinancial support from FIVIN, Spain; nonfinancial support from Fundacion Dieta Mediterranea, Spain, nonfinancial support from Universidad Internacional de
Publisher Copyright:
© 2017 American Society for Nutrition.
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Background: Potatoes have a high glycemic load but also antioxidants, vitamins, and minerals. It is unclear what mechanisms are involved in relation to their effect on blood pressure (BP) and hypertension. Objectives: This study aimed to assess the association between potato consumption, BP changes, and the risk of hypertension in 2 Spanish populations. Methods: Separate analyses were performed in PREDIMED (PREvención con DIeta MEDiterránea), a multicenter nutrition intervention trial of adults aged 55-80 y, and the SUN (Seguimiento Universidad de Navarra) project, a prospective cohort made up of university graduates and educated adults with ages (means±SDs) of 42.7±13.3 y for men and 35.1± 10.7 y for women. In PREDIMED, generalized estimating equations adjusted for lifestyle and dietary characteristics were used to assess changes in BP across quintiles of total potato consumption during a 4-y follow-up. Controlled BP values (systolic BP < 140 mm Hg and diastolic BP < 90 mm Hg) during follow-up were also assessed. For SUN, multivariateadjusted HRs for incident hypertension during a mean 6.7-y follow-up were calculated. Results: In PREDIMED, the total potato intake was 81.9 ± 40.6 g/d. No overall differences in systolic or diastolic BP changes were detected based on consumption of potatoes. For total potatoes, the mean difference in change between quintile 5 (highest intake) and quintile 1 (lowest intake) in systolic BP after multivariate adjustment was 20.90 mm Hg (95% CI: -2.56, 0.76 mm Hg; P-trend = 0.1) and for diastolic BP was 20.02 mm Hg (95% CI: -0.93, 0.89 mm Hg; P-trend = 0.8). In SUN, the total potato consumption was 52.7 ± 33.6 g/d, and no significant association between potato consumption and hypertension incidence was observed in the fully adjusted HR for total potato consumption (quintile 5 compared with quintile 1: 0.98; 95% CI: 0.80, 1.19; P-trend = 0.8). Conclusions: Potato consumption is not associated with changes over 4 y in blood pressure among older adults in Spain or with the risk of hypertension among Spanish adults.
AB - Background: Potatoes have a high glycemic load but also antioxidants, vitamins, and minerals. It is unclear what mechanisms are involved in relation to their effect on blood pressure (BP) and hypertension. Objectives: This study aimed to assess the association between potato consumption, BP changes, and the risk of hypertension in 2 Spanish populations. Methods: Separate analyses were performed in PREDIMED (PREvención con DIeta MEDiterránea), a multicenter nutrition intervention trial of adults aged 55-80 y, and the SUN (Seguimiento Universidad de Navarra) project, a prospective cohort made up of university graduates and educated adults with ages (means±SDs) of 42.7±13.3 y for men and 35.1± 10.7 y for women. In PREDIMED, generalized estimating equations adjusted for lifestyle and dietary characteristics were used to assess changes in BP across quintiles of total potato consumption during a 4-y follow-up. Controlled BP values (systolic BP < 140 mm Hg and diastolic BP < 90 mm Hg) during follow-up were also assessed. For SUN, multivariateadjusted HRs for incident hypertension during a mean 6.7-y follow-up were calculated. Results: In PREDIMED, the total potato intake was 81.9 ± 40.6 g/d. No overall differences in systolic or diastolic BP changes were detected based on consumption of potatoes. For total potatoes, the mean difference in change between quintile 5 (highest intake) and quintile 1 (lowest intake) in systolic BP after multivariate adjustment was 20.90 mm Hg (95% CI: -2.56, 0.76 mm Hg; P-trend = 0.1) and for diastolic BP was 20.02 mm Hg (95% CI: -0.93, 0.89 mm Hg; P-trend = 0.8). In SUN, the total potato consumption was 52.7 ± 33.6 g/d, and no significant association between potato consumption and hypertension incidence was observed in the fully adjusted HR for total potato consumption (quintile 5 compared with quintile 1: 0.98; 95% CI: 0.80, 1.19; P-trend = 0.8). Conclusions: Potato consumption is not associated with changes over 4 y in blood pressure among older adults in Spain or with the risk of hypertension among Spanish adults.
KW - Blood pressure
KW - Hypertension
KW - Mediterranean
KW - PREDIMED study
KW - Potatoes
KW - SUN cohort
UR - http://www.scopus.com/inward/record.url?scp=85036585893&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85036585893&partnerID=8YFLogxK
U2 - 10.3945/jn.117.252254
DO - 10.3945/jn.117.252254
M3 - Article
C2 - 29046405
AN - SCOPUS:85036585893
SN - 0022-3166
VL - 147
SP - 2272
EP - 2281
JO - Journal of Nutrition
JF - Journal of Nutrition
IS - 12
ER -