Posttraumatic stress disorder increases risk for suicide attempt in adults with recurrent major depression

Daniel Stevens, Holly Wilcox, Dean F Mackinnon, Francis M Mondimore, Barbara W Schweizer, Dunya Jancic, William H. Coryell, Myrna M. Weissman, Douglas F. Levinson, James Bennett Potash

Research output: Contribution to journalArticle

Abstract

Background Genetics of Recurrent Early-Onset Depression study (GenRED II) data were used to examine the relationship between posttraumatic stress disorder (PTSD) and attempted suicide in a population of 1,433 individuals with recurrent early-onset major depressive disorder (MDD). We tested the hypothesis that PTSD resulting from assaultive trauma increases risk for attempted suicide among individuals with recurrent MDD. Methods Data on lifetime trauma exposures and clinical symptoms were collected using the Diagnostic Interview for Genetic Studies version 3.0 and best estimate diagnoses of MDD, PTSD, and other DSM-IV Axis I disorders were reported with best estimated age of onset. Results The lifetime prevalence of suicide attempt in this sample was 28%. Lifetime PTSD was diagnosed in 205 (14.3%) participants. We used discrete time-survival analyses to take into account timing in the PTSD-suicide attempt relationship while adjusting for demographic variables (gender, race, age, and education level) and comorbid diagnoses prior to trauma exposure. PTSD was an independent predictor of subsequent suicide attempt (HR = 2.5, 95% CI: 1.6, 3.8; P

Original languageEnglish (US)
Pages (from-to)940-946
Number of pages7
JournalDepression and Anxiety
Volume30
Issue number10
DOIs
StatePublished - Oct 2013

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Keywords

  • anxiety/anxiety disorders
  • depression
  • PTSD/posttraumatic stress disorder
  • suicide/self harm
  • trauma

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

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