Postoperative hypocalcemia after thyroidectomy for Graves' disease

Catherine E. Pesce, Zita Shiue, Hua Ling Tsai, Christopher B Umbricht, Ralph P Tufano, Alan P B Dackiw, Jeanne Kowalski, Martha A. Zeiger

Research output: Contribution to journalArticle

Abstract

Background: It is believed that patients who undergo thyroidectomy for Graves' disease are more likely to experience postoperative hypocalcemia than patients undergoing total thyroidectomy for other indications. However, no study has directly compared these two groups of patients. The aim of this study was to determine whether there was an increased incidence or severity of postoperative hypocalcemia in patients who underwent thyroidectomy for Graves' disease. Methods: An institutional review board-approved database was created of all patients who underwent thyroidectomy from 1998 to 2009 at the Johns Hopkins Hospital. There were a total of 68 patients with Graves' disease who underwent surgery. Fifty-five patients who underwent total thyroidectomy were randomly selected and served as control subjects. An analysis was conducted that examined potential covariates for postoperative hypocalcemia, including age, gender, ethnicity, preoperative alkaline phosphatase level, size of goiter, whether parathyroid tissue or glands were present in the specimen, and the reason the patient underwent surgery. Specific outcomes examined were calcium levels on postoperative day 1, whether or not patients experienced symptoms of hypocalcemia, whether or not Rocaltrol was required, the number of calcium tablets prescribed upon discharge, whether or not postoperative tetany occurred, and calcium levels 1 month after discharge. Results: Each outcome was analyzed using a logistic regression. Graves' disease patients had a significantly (p-value

Original languageEnglish (US)
Pages (from-to)1279-1283
Number of pages5
JournalThyroid
Volume20
Issue number11
DOIs
StatePublished - Nov 1 2010

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Hypocalcemia
Graves Disease
Thyroidectomy
Calcium
Tetany
Calcitriol
Research Ethics Committees
Goiter
Tablets
Alkaline Phosphatase
Logistic Models
Databases

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Pesce, C. E., Shiue, Z., Tsai, H. L., Umbricht, C. B., Tufano, R. P., Dackiw, A. P. B., ... Zeiger, M. A. (2010). Postoperative hypocalcemia after thyroidectomy for Graves' disease. Thyroid, 20(11), 1279-1283. https://doi.org/10.1089/thy.2010.0047

Postoperative hypocalcemia after thyroidectomy for Graves' disease. / Pesce, Catherine E.; Shiue, Zita; Tsai, Hua Ling; Umbricht, Christopher B; Tufano, Ralph P; Dackiw, Alan P B; Kowalski, Jeanne; Zeiger, Martha A.

In: Thyroid, Vol. 20, No. 11, 01.11.2010, p. 1279-1283.

Research output: Contribution to journalArticle

Pesce, CE, Shiue, Z, Tsai, HL, Umbricht, CB, Tufano, RP, Dackiw, APB, Kowalski, J & Zeiger, MA 2010, 'Postoperative hypocalcemia after thyroidectomy for Graves' disease', Thyroid, vol. 20, no. 11, pp. 1279-1283. https://doi.org/10.1089/thy.2010.0047
Pesce, Catherine E. ; Shiue, Zita ; Tsai, Hua Ling ; Umbricht, Christopher B ; Tufano, Ralph P ; Dackiw, Alan P B ; Kowalski, Jeanne ; Zeiger, Martha A. / Postoperative hypocalcemia after thyroidectomy for Graves' disease. In: Thyroid. 2010 ; Vol. 20, No. 11. pp. 1279-1283.
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