TY - JOUR
T1 - Postmortem neurochemistry in schizophrenia
AU - Bracha, H. S.
AU - Kleinman, J. E.
N1 - Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 1986
Y1 - 1986
N2 - The renaissance in postmortem studies in schizophrenia is in full bloom. Although there is no shortage of findings, there have been significant problems with replications and interpretations. Regardless, the postmortem approach remains a valid and promising one. Thus far, it has allowed for the testing of a number of hypotheses involving catecholamines, indoleamines, and neuropeptides in schizophrenia. It is hoped that new approaches, such as autoradiography and automated cell counting, will add new dimensions to postmortem studies of schizophrenia. If these studies can be coupled with premortem exams of patients, perhaps new inroads can be made in the understanding and treatment of the schizophrenic syndrome.
AB - The renaissance in postmortem studies in schizophrenia is in full bloom. Although there is no shortage of findings, there have been significant problems with replications and interpretations. Regardless, the postmortem approach remains a valid and promising one. Thus far, it has allowed for the testing of a number of hypotheses involving catecholamines, indoleamines, and neuropeptides in schizophrenia. It is hoped that new approaches, such as autoradiography and automated cell counting, will add new dimensions to postmortem studies of schizophrenia. If these studies can be coupled with premortem exams of patients, perhaps new inroads can be made in the understanding and treatment of the schizophrenic syndrome.
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U2 - 10.1016/s0193-953x(18)30639-7
DO - 10.1016/s0193-953x(18)30639-7
M3 - Review article
C2 - 2421270
AN - SCOPUS:0022656517
SN - 0193-953X
VL - 9
SP - 133
EP - 141
JO - Psychiatric Clinics of North America
JF - Psychiatric Clinics of North America
IS - 1
ER -