Postmortem measurements of neuropeptides in human brain

Joel Kleinman, M. Iadarola, S. Govoni

Research output: Contribution to journalArticle

Abstract

Met-enkephalin concentrations in caudate nuclei are decreased in chronic paranoid schizophrenic patients; met-enkephalin concentrations in caudate nuclei are increased in opiate abusers; and substance P concentrations in caudate nuclei are increased in some patients with psychoses other than schizophrenia. The significance of these findings remains to be determined. Although drugs may account for these findings, especially in opiate abusers, they do not appear to be responsible for the other findings. With regard to substance P concentrations, further studies with patients with affective psychoses should be considered. Regardless, the postmortem approach for testing hypotheses that neuropeptides are involved in mental illness appears to be a promising one.

Original languageEnglish (US)
Pages (from-to)375-377
Number of pages3
JournalPsychopharmacology Bulletin
Volume19
Issue number3
StatePublished - 1983
Externally publishedYes

Fingerprint

Opiate Alkaloids
Caudate Nucleus
Neuropeptides
Methionine Enkephalin
Substance P
Brain
Psychotic Affective Disorders
Psychotic Disorders
Schizophrenia
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Postmortem measurements of neuropeptides in human brain. / Kleinman, Joel; Iadarola, M.; Govoni, S.

In: Psychopharmacology Bulletin, Vol. 19, No. 3, 1983, p. 375-377.

Research output: Contribution to journalArticle

Kleinman, J, Iadarola, M & Govoni, S 1983, 'Postmortem measurements of neuropeptides in human brain', Psychopharmacology Bulletin, vol. 19, no. 3, pp. 375-377.
Kleinman, Joel ; Iadarola, M. ; Govoni, S. / Postmortem measurements of neuropeptides in human brain. In: Psychopharmacology Bulletin. 1983 ; Vol. 19, No. 3. pp. 375-377.
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