TY - JOUR
T1 - Postmortem magnetic resonance imaging to guide the pathologic cut
T2 - Individualized, 3-dimensionally printed cutting boxes for fixed brains
AU - Absinta, Martina
AU - Nair, Govind
AU - Filippi, Massimo
AU - Ray-Chaudhury, Abhik
AU - Reyes-Mantilla, Maria I.
AU - Pardo, Carlos A.
AU - Reich, Daniel S.
PY - 2014/8
Y1 - 2014/8
N2 - Interfacing magnetic resonance imaging (MRI) with pathology is critically important for understanding the pathologic basis of MRI signal changes in vivo and for clinicopathologic correlations. Postmortem MRI is an intermediate step in this process; unfortunately, however, relating the data to standard pathologic sections, which are relatively thick and often nonparallel, is both time-consuming and insufficiently accurate. The aim of this project was to develop technology to integrate postmortem, high-resolution, whole-brain MRI into the planning and execution of pathologic analysis through precise localization of the target and coordinates of cut. Compared with standard pathologic sectioning, the use of an individualized, 3-dimensionally printed cutting box - designed based on postmortem MRI of formalin-fixed whole brains - improved the speed, quality, and accuracy of radiologic-pathologic correlations and, specifically, the histopathologic localization of imaging findings. The technology described herein is easily implemented, applicable to any brain disorder, and potentially extendable to other organs. From the point of view of the pathologist, this technique can improve localization of small or subtle abnormalities, whereas from the point of view of the radiologist, it has the potential to improve understanding of MRI signal changes observed in diseases.
AB - Interfacing magnetic resonance imaging (MRI) with pathology is critically important for understanding the pathologic basis of MRI signal changes in vivo and for clinicopathologic correlations. Postmortem MRI is an intermediate step in this process; unfortunately, however, relating the data to standard pathologic sections, which are relatively thick and often nonparallel, is both time-consuming and insufficiently accurate. The aim of this project was to develop technology to integrate postmortem, high-resolution, whole-brain MRI into the planning and execution of pathologic analysis through precise localization of the target and coordinates of cut. Compared with standard pathologic sectioning, the use of an individualized, 3-dimensionally printed cutting box - designed based on postmortem MRI of formalin-fixed whole brains - improved the speed, quality, and accuracy of radiologic-pathologic correlations and, specifically, the histopathologic localization of imaging findings. The technology described herein is easily implemented, applicable to any brain disorder, and potentially extendable to other organs. From the point of view of the pathologist, this technique can improve localization of small or subtle abnormalities, whereas from the point of view of the radiologist, it has the potential to improve understanding of MRI signal changes observed in diseases.
KW - Cutting box
KW - High resolution
KW - MRI-Pathology correlations
KW - Postmortem MRI
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U2 - 10.1097/NEN.0000000000000096
DO - 10.1097/NEN.0000000000000096
M3 - Article
C2 - 25007244
AN - SCOPUS:84904747084
SN - 0022-3069
VL - 73
SP - 780
EP - 788
JO - Journal of neuropathology and experimental neurology
JF - Journal of neuropathology and experimental neurology
IS - 8
ER -