Postmortem central catecholamines and antemortem cognitive impairment in elderly schizophrenics and controls

T. Peter Bridge, Joel E. Kleinman, Faroum Karoum, Richard Jed Wyatt

Research output: Contribution to journalArticle

Abstract

Central catecholamine concentrations were determined in autopsy brain samples from 19 elderly schizophrenic patients and controls. Data from the hypothalamus and nucleus accumbens demonstrate altered catecholamine metabolism associated with cognitive impairment in these subjects. Both loci show decrements of norepinephrine concentrations, while the nucleus accumbens samples also show increased dopamine, dihydroxyphenylacetic acid, and 3-methoxy-4-hydroxyphenylglycol concentrations associated with dementia in these subjects. The data argue for examination of catecholamine metabolism with respect to dementia in a broad range of elderly subjects.

Original languageEnglish (US)
Pages (from-to)57-61
Number of pages5
JournalNeuropsychobiology
Volume14
Issue number2
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

Keywords

  • Aged schizophrenics
  • Central catecholamines
  • Cognitive impairment
  • Postmortem
  • Schizophrenia

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Psychiatry and Mental health
  • Biological Psychiatry

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