Postmortem central catecholamines and antemortem cognitive impairment in elderly schizophrenics and controls

T. Peter Bridge; Joel E. Kleinman; Faroum Karoum; Richard Jed Wyatt

doi:10.1159/000118205

Postmortem central catecholamines and antemortem cognitive impairment in elderly schizophrenics and controls

T. Peter Bridge, Joel E. Kleinman, Faroum Karoum, Richard Jed Wyatt

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Central catecholamine concentrations were determined in autopsy brain samples from 19 elderly schizophrenic patients and controls. Data from the hypothalamus and nucleus accumbens demonstrate altered catecholamine metabolism associated with cognitive impairment in these subjects. Both loci show decrements of norepinephrine concentrations, while the nucleus accumbens samples also show increased dopamine, dihydroxyphenylacetic acid, and 3-methoxy-4-hydroxyphenylglycol concentrations associated with dementia in these subjects. The data argue for examination of catecholamine metabolism with respect to dementia in a broad range of elderly subjects.

Original language	English (US)
Pages (from-to)	57-61
Number of pages	5
Journal	Neuropsychobiology
Volume	14
Issue number	2
DOIs	https://doi.org/10.1159/000118205
State	Published - 1985
Externally published	Yes

Keywords

Aged schizophrenics
Central catecholamines
Cognitive impairment
Postmortem
Schizophrenia

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Psychiatry and Mental health
Biological Psychiatry

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10.1159/000118205

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title = "Postmortem central catecholamines and antemortem cognitive impairment in elderly schizophrenics and controls",

abstract = "Central catecholamine concentrations were determined in autopsy brain samples from 19 elderly schizophrenic patients and controls. Data from the hypothalamus and nucleus accumbens demonstrate altered catecholamine metabolism associated with cognitive impairment in these subjects. Both loci show decrements of norepinephrine concentrations, while the nucleus accumbens samples also show increased dopamine, dihydroxyphenylacetic acid, and 3-methoxy-4-hydroxyphenylglycol concentrations associated with dementia in these subjects. The data argue for examination of catecholamine metabolism with respect to dementia in a broad range of elderly subjects.",

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doi = "10.1159/000118205",

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AU - Kleinman, Joel E.

AU - Karoum, Faroum

AU - Wyatt, Richard Jed

PY - 1985

Y1 - 1985

N2 - Central catecholamine concentrations were determined in autopsy brain samples from 19 elderly schizophrenic patients and controls. Data from the hypothalamus and nucleus accumbens demonstrate altered catecholamine metabolism associated with cognitive impairment in these subjects. Both loci show decrements of norepinephrine concentrations, while the nucleus accumbens samples also show increased dopamine, dihydroxyphenylacetic acid, and 3-methoxy-4-hydroxyphenylglycol concentrations associated with dementia in these subjects. The data argue for examination of catecholamine metabolism with respect to dementia in a broad range of elderly subjects.

AB - Central catecholamine concentrations were determined in autopsy brain samples from 19 elderly schizophrenic patients and controls. Data from the hypothalamus and nucleus accumbens demonstrate altered catecholamine metabolism associated with cognitive impairment in these subjects. Both loci show decrements of norepinephrine concentrations, while the nucleus accumbens samples also show increased dopamine, dihydroxyphenylacetic acid, and 3-methoxy-4-hydroxyphenylglycol concentrations associated with dementia in these subjects. The data argue for examination of catecholamine metabolism with respect to dementia in a broad range of elderly subjects.

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KW - Central catecholamines

KW - Cognitive impairment

KW - Postmortem

KW - Schizophrenia

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Postmortem central catecholamines and antemortem cognitive impairment in elderly schizophrenics and controls

Abstract

Keywords

ASJC Scopus subject areas

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