Postmenopausal bilateral oophorectomy is not associated with increased fracture risk in older women

Diana M. Antoniucci, Deborah E. Sellmeyer, Jane A. Cauley, Kristine E. Ensrud, Jennifer L. Schneider, Kimberly K. Vesco, Steven R. Cummings, L. Joseph Melton

Research output: Contribution to journalArticle

Abstract

We studied whether oophorectomy performed after menopause is associated with an increased risk of hip or vertebral fractures in 6295 Study of Osteoporotic Fractures participants. There was no association between postmenopausal oophorectomy and the risk of hip or vertebral fractures. Introduction: Bilateral oophorectomy after natural menopause has been associated with an increased risk of osteoporotic fractures, potentially because of a decline in serum estradiol and testosterone levels after the oophorectomy. We prospectively tested this hypothesis in the Study of Osteoporotic Fractures (SOF). Materials and Methods: We studied 6295 white women ≥65 years of age participating in the SOF who were not taking estrogen therapy at baseline. Hip fracture analyses included 708 hip fractures; vertebral fracture analyses included 267 incident vertebral fractures. Baseline serum estradiol and free testosterone values were available in a small subset of participants. Results and Conclusion: There were no significant differences in age, weight, or BMD between the women who underwent postmenopausal oophorectomy (n = 583) and those who did not (n = 5712). Free testosterone levels were significantly lower among women who had a postmenopausal oophorectomy. A history of postmenopausal oophorectomy was not associated with an increased risk of hip (hazard ratio [HR] = 1.1; 95% CI = 0.9-1.5) or vertebral fracture (HR = 0.7; 95% CI = 0.5-1.2). The relationship between oophorectomy and hip fracture was not altered by adding serum estradiol level (HR = 1.3; 95% CI = 0.5-3.2) or serum free testosterone level (HR = 1.7; 95% CI = 0.8-3.7) to the model. In summary, postmenopausal oophorectomy was not associated with an increased risk of hip or vertebral fracture in this cohort. These results are in contrast to previous findings, suggesting that the relationship between postmenopausal oophorectomy and fractures is not fully elucidated and that incidental oophorectomy after menopause should still be considered carefully in each potential patient.

Original languageEnglish (US)
Pages (from-to)741-747
Number of pages7
JournalJournal of Bone and Mineral Research
Volume20
Issue number5
DOIs
StatePublished - May 2005
Externally publishedYes

Fingerprint

Ovariectomy
Osteoporotic Fractures
Testosterone
Hip
Hip Fractures
Menopause
Estradiol
Serum
Estrogens
Weights and Measures

Keywords

  • Epidemiology
  • Hip fracture
  • Oophorectomy
  • Sex steroids
  • Vertebral fracture

ASJC Scopus subject areas

  • Surgery

Cite this

Antoniucci, D. M., Sellmeyer, D. E., Cauley, J. A., Ensrud, K. E., Schneider, J. L., Vesco, K. K., ... Melton, L. J. (2005). Postmenopausal bilateral oophorectomy is not associated with increased fracture risk in older women. Journal of Bone and Mineral Research, 20(5), 741-747. https://doi.org/10.1359/JBMR.041220

Postmenopausal bilateral oophorectomy is not associated with increased fracture risk in older women. / Antoniucci, Diana M.; Sellmeyer, Deborah E.; Cauley, Jane A.; Ensrud, Kristine E.; Schneider, Jennifer L.; Vesco, Kimberly K.; Cummings, Steven R.; Melton, L. Joseph.

In: Journal of Bone and Mineral Research, Vol. 20, No. 5, 05.2005, p. 741-747.

Research output: Contribution to journalArticle

Antoniucci, DM, Sellmeyer, DE, Cauley, JA, Ensrud, KE, Schneider, JL, Vesco, KK, Cummings, SR & Melton, LJ 2005, 'Postmenopausal bilateral oophorectomy is not associated with increased fracture risk in older women', Journal of Bone and Mineral Research, vol. 20, no. 5, pp. 741-747. https://doi.org/10.1359/JBMR.041220
Antoniucci, Diana M. ; Sellmeyer, Deborah E. ; Cauley, Jane A. ; Ensrud, Kristine E. ; Schneider, Jennifer L. ; Vesco, Kimberly K. ; Cummings, Steven R. ; Melton, L. Joseph. / Postmenopausal bilateral oophorectomy is not associated with increased fracture risk in older women. In: Journal of Bone and Mineral Research. 2005 ; Vol. 20, No. 5. pp. 741-747.
@article{fe695640853841a8b5f6e372f1fd0353,
title = "Postmenopausal bilateral oophorectomy is not associated with increased fracture risk in older women",
abstract = "We studied whether oophorectomy performed after menopause is associated with an increased risk of hip or vertebral fractures in 6295 Study of Osteoporotic Fractures participants. There was no association between postmenopausal oophorectomy and the risk of hip or vertebral fractures. Introduction: Bilateral oophorectomy after natural menopause has been associated with an increased risk of osteoporotic fractures, potentially because of a decline in serum estradiol and testosterone levels after the oophorectomy. We prospectively tested this hypothesis in the Study of Osteoporotic Fractures (SOF). Materials and Methods: We studied 6295 white women ≥65 years of age participating in the SOF who were not taking estrogen therapy at baseline. Hip fracture analyses included 708 hip fractures; vertebral fracture analyses included 267 incident vertebral fractures. Baseline serum estradiol and free testosterone values were available in a small subset of participants. Results and Conclusion: There were no significant differences in age, weight, or BMD between the women who underwent postmenopausal oophorectomy (n = 583) and those who did not (n = 5712). Free testosterone levels were significantly lower among women who had a postmenopausal oophorectomy. A history of postmenopausal oophorectomy was not associated with an increased risk of hip (hazard ratio [HR] = 1.1; 95{\%} CI = 0.9-1.5) or vertebral fracture (HR = 0.7; 95{\%} CI = 0.5-1.2). The relationship between oophorectomy and hip fracture was not altered by adding serum estradiol level (HR = 1.3; 95{\%} CI = 0.5-3.2) or serum free testosterone level (HR = 1.7; 95{\%} CI = 0.8-3.7) to the model. In summary, postmenopausal oophorectomy was not associated with an increased risk of hip or vertebral fracture in this cohort. These results are in contrast to previous findings, suggesting that the relationship between postmenopausal oophorectomy and fractures is not fully elucidated and that incidental oophorectomy after menopause should still be considered carefully in each potential patient.",
keywords = "Epidemiology, Hip fracture, Oophorectomy, Sex steroids, Vertebral fracture",
author = "Antoniucci, {Diana M.} and Sellmeyer, {Deborah E.} and Cauley, {Jane A.} and Ensrud, {Kristine E.} and Schneider, {Jennifer L.} and Vesco, {Kimberly K.} and Cummings, {Steven R.} and Melton, {L. Joseph}",
year = "2005",
month = "5",
doi = "10.1359/JBMR.041220",
language = "English (US)",
volume = "20",
pages = "741--747",
journal = "Journal of Bone and Mineral Research",
issn = "0884-0431",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Postmenopausal bilateral oophorectomy is not associated with increased fracture risk in older women

AU - Antoniucci, Diana M.

AU - Sellmeyer, Deborah E.

AU - Cauley, Jane A.

AU - Ensrud, Kristine E.

AU - Schneider, Jennifer L.

AU - Vesco, Kimberly K.

AU - Cummings, Steven R.

AU - Melton, L. Joseph

PY - 2005/5

Y1 - 2005/5

N2 - We studied whether oophorectomy performed after menopause is associated with an increased risk of hip or vertebral fractures in 6295 Study of Osteoporotic Fractures participants. There was no association between postmenopausal oophorectomy and the risk of hip or vertebral fractures. Introduction: Bilateral oophorectomy after natural menopause has been associated with an increased risk of osteoporotic fractures, potentially because of a decline in serum estradiol and testosterone levels after the oophorectomy. We prospectively tested this hypothesis in the Study of Osteoporotic Fractures (SOF). Materials and Methods: We studied 6295 white women ≥65 years of age participating in the SOF who were not taking estrogen therapy at baseline. Hip fracture analyses included 708 hip fractures; vertebral fracture analyses included 267 incident vertebral fractures. Baseline serum estradiol and free testosterone values were available in a small subset of participants. Results and Conclusion: There were no significant differences in age, weight, or BMD between the women who underwent postmenopausal oophorectomy (n = 583) and those who did not (n = 5712). Free testosterone levels were significantly lower among women who had a postmenopausal oophorectomy. A history of postmenopausal oophorectomy was not associated with an increased risk of hip (hazard ratio [HR] = 1.1; 95% CI = 0.9-1.5) or vertebral fracture (HR = 0.7; 95% CI = 0.5-1.2). The relationship between oophorectomy and hip fracture was not altered by adding serum estradiol level (HR = 1.3; 95% CI = 0.5-3.2) or serum free testosterone level (HR = 1.7; 95% CI = 0.8-3.7) to the model. In summary, postmenopausal oophorectomy was not associated with an increased risk of hip or vertebral fracture in this cohort. These results are in contrast to previous findings, suggesting that the relationship between postmenopausal oophorectomy and fractures is not fully elucidated and that incidental oophorectomy after menopause should still be considered carefully in each potential patient.

AB - We studied whether oophorectomy performed after menopause is associated with an increased risk of hip or vertebral fractures in 6295 Study of Osteoporotic Fractures participants. There was no association between postmenopausal oophorectomy and the risk of hip or vertebral fractures. Introduction: Bilateral oophorectomy after natural menopause has been associated with an increased risk of osteoporotic fractures, potentially because of a decline in serum estradiol and testosterone levels after the oophorectomy. We prospectively tested this hypothesis in the Study of Osteoporotic Fractures (SOF). Materials and Methods: We studied 6295 white women ≥65 years of age participating in the SOF who were not taking estrogen therapy at baseline. Hip fracture analyses included 708 hip fractures; vertebral fracture analyses included 267 incident vertebral fractures. Baseline serum estradiol and free testosterone values were available in a small subset of participants. Results and Conclusion: There were no significant differences in age, weight, or BMD between the women who underwent postmenopausal oophorectomy (n = 583) and those who did not (n = 5712). Free testosterone levels were significantly lower among women who had a postmenopausal oophorectomy. A history of postmenopausal oophorectomy was not associated with an increased risk of hip (hazard ratio [HR] = 1.1; 95% CI = 0.9-1.5) or vertebral fracture (HR = 0.7; 95% CI = 0.5-1.2). The relationship between oophorectomy and hip fracture was not altered by adding serum estradiol level (HR = 1.3; 95% CI = 0.5-3.2) or serum free testosterone level (HR = 1.7; 95% CI = 0.8-3.7) to the model. In summary, postmenopausal oophorectomy was not associated with an increased risk of hip or vertebral fracture in this cohort. These results are in contrast to previous findings, suggesting that the relationship between postmenopausal oophorectomy and fractures is not fully elucidated and that incidental oophorectomy after menopause should still be considered carefully in each potential patient.

KW - Epidemiology

KW - Hip fracture

KW - Oophorectomy

KW - Sex steroids

KW - Vertebral fracture

UR - http://www.scopus.com/inward/record.url?scp=17644419265&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17644419265&partnerID=8YFLogxK

U2 - 10.1359/JBMR.041220

DO - 10.1359/JBMR.041220

M3 - Article

VL - 20

SP - 741

EP - 747

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

SN - 0884-0431

IS - 5

ER -