Post‐ischemic coma in rat: effect of different pre‐ischemic blood glucose levels on cerebral metabolic recovery after ischemia

EUGENIUSZ SIEMKOWICZ, ALBERT GJEDDE

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Abstract

Hyper‐, normo‐, and hypoglycemic rats were exposed to 10 min of complete cerebral ischemia. Regional cerebral blood flow (CBF), blood‐brain glucose transfer, and cerebral consumption of oxygen and glucose were measured before, as well as three and 60 minutes after ischemia. Three min after ischemia, no differences were observed between the 3 groups of rats. One h after ischemia, the hyperglycemic rats in comparison to those of the other groups had similar whole‐brain CBF and glucose consumption but appreciately lower oxygen consumption, indicating continued non‐oxidative use of glucose in the hyperglycemic group. In general, regional CBF values exceeded the control value by 100–200% 3 min after ischemia and were reduced to 50% of control at 1 h after ischemia, at which time the rats were still comatose. In the brain stem of hyperglycemic rats, blood flow, however, remained elevated after ischemia. Thus, the significantly increased mortality observed in rats hyperglycemic before, during and after ischemia (Siemkowicz & Hansen 1978) was the result, not of impaired postischemic CBF, but of ischemic or postischemic damage to brain cells. We suggest that the damaging factor in the hyperglycemic group is increased lactacidosis associated with prolonged anaerobic glycolysis.

Original languageEnglish (US)
Pages (from-to)225-232
Number of pages8
JournalActa Physiologica Scandinavica
Volume110
Issue number3
DOIs
StatePublished - Nov 1980

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Keywords

  • Cerebral ischemia
  • cerebral blood flow
  • hyperglycemia
  • postischemic recovery

ASJC Scopus subject areas

  • Physiology

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