Posterior cingulate γ-aminobutyric acid and glutamate/glutamine are reduced in amnestic mild cognitive impairment and are unrelated to amyloid deposition and apolipoprotein E genotype

Florian Riese, Anton Gietl, Niklaus Zölch, Anke Henning, Ruth O'Gorman, Andrea M. Kälin, Sandra E. Leh, Alfred Buck, Geoffrey Warnock, Richard A.E. Edden, Roger Luechinger, Christoph Hock, Spyros Kollias, Lars Michels

Research output: Contribution to journalArticle

Abstract

The biomarker potential of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) for the invivo characterization of preclinical stages in Alzheimer's disease has not yet been explored. We measured GABA, glutamate+ glutamine (Glx), and N-acetyl-aspartate (NAA) levels by single-voxel MEGA-PRESS magnetic resonance spectroscopy in the posterior cingulate cortex of 21 elderly subjects and 15 patients with amnestic mild cognitive impairment. Participants underwent Pittsburgh Compound B positron emission tomography, apolipoprotein E (APOE) genotyping, and neuropsychological examination. GABA, Glx, and NAA levels were significantly lower in patients. NAA was lower in Pittsburgh Compound B-positive subjects and APOE ε4 allele carriers. GABA, Glx, and NAA levels were positively correlated to CERAD word learning scores. Reductions in GABA, Glx, and NAA levels may serve as metabolic biomarkers for cognitive impairment in amnestic mild cognitive impairment. Because GABA and Glx do not seem to reflect amyloid β deposition or APOE genotype, they are less likely biomarker candidates for preclinical Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)53-59
Number of pages7
JournalNeurobiology of aging
Volume36
Issue number1
DOIs
StatePublished - Jan 1 2015

Keywords

  • APOE
  • Alzheimer
  • Beta-amyloid
  • Dementia
  • GABA
  • Glutamate
  • Glx
  • MRS
  • Magnetic resonance spectroscopy
  • Mild cognitive impairment
  • PiB
  • Posterior cingulate cortex

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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    Riese, F., Gietl, A., Zölch, N., Henning, A., O'Gorman, R., Kälin, A. M., Leh, S. E., Buck, A., Warnock, G., Edden, R. A. E., Luechinger, R., Hock, C., Kollias, S., & Michels, L. (2015). Posterior cingulate γ-aminobutyric acid and glutamate/glutamine are reduced in amnestic mild cognitive impairment and are unrelated to amyloid deposition and apolipoprotein E genotype. Neurobiology of aging, 36(1), 53-59. https://doi.org/10.1016/j.neurobiolaging.2014.07.030