Post-traumatic stress disorder, drug abuse and migraine: New findings from the National Comorbidity Survey Replication (NCS-R)

B. Lee Peterlin, Andrea L. Rosso, Fred D. Sheftell, David J. Libon, Jana M. Mossey, Kathleen R. Merikangas

Research output: Contribution to journalArticle

Abstract

Background: Post-traumatic stress disorder (PTSD) has been shown to be associated with migraine and drug abuse. Methods: This was an analysis of data from the National Comorbidity Survey Replication (NCS-R) to evaluate the association of PTSD in those with episodic migraine (EM) and chronic daily headache (CDH). Results: Our sample consisted of 5,692 participants. Lifetime and 12-month prevalence rates of PTSD were increased in those with EM and CDH. After adjustments, the lifetime odds ratio (OR) of PTSD was greater in those with EM (OR 3.07 confidence interval [CI]: 2.12, 4.46) compared to those without headache; was greater in men than women with EM (men: OR 6.86; CI: 3.11, 15.11; women: OR 2.77; CI: 1.83, 4.21); and was comparable or greater than the association between migraine with depression or anxiety. The lifetime OR of PTSD was also increased in CDH sufferers. The OR of illicit drug abuse was not increased in those with EM or CDH unless co-occurring with PTSD or depression. Conclusion: The lifetime and 12-month OR of PTSD is increased in those with migraine or CDH, and is greater in men than women with migraine. The lifetime and 12-month OR of illicit drug abuse is not increased in those with migraine or CDH unless co-occurring with PTSD or depression.

Original languageEnglish (US)
Pages (from-to)235-244
Number of pages10
JournalCephalalgia
Volume31
Issue number2
DOIs
StatePublished - Feb 2011

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Post-Traumatic Stress Disorders
Migraine Disorders
Substance-Related Disorders
Comorbidity
Headache Disorders
Odds Ratio
Street Drugs
Confidence Intervals
Depression
Surveys and Questionnaires
Social Adjustment
Headache
Anxiety

Keywords

  • Anxiety
  • chronic daily headache
  • depression
  • drug abuse
  • migraine
  • post-traumatic stress disorder
  • smoking

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Lee Peterlin, B., Rosso, A. L., Sheftell, F. D., Libon, D. J., Mossey, J. M., & Merikangas, K. R. (2011). Post-traumatic stress disorder, drug abuse and migraine: New findings from the National Comorbidity Survey Replication (NCS-R). Cephalalgia, 31(2), 235-244. https://doi.org/10.1177/0333102410378051

Post-traumatic stress disorder, drug abuse and migraine : New findings from the National Comorbidity Survey Replication (NCS-R). / Lee Peterlin, B.; Rosso, Andrea L.; Sheftell, Fred D.; Libon, David J.; Mossey, Jana M.; Merikangas, Kathleen R.

In: Cephalalgia, Vol. 31, No. 2, 02.2011, p. 235-244.

Research output: Contribution to journalArticle

Lee Peterlin, B, Rosso, AL, Sheftell, FD, Libon, DJ, Mossey, JM & Merikangas, KR 2011, 'Post-traumatic stress disorder, drug abuse and migraine: New findings from the National Comorbidity Survey Replication (NCS-R)', Cephalalgia, vol. 31, no. 2, pp. 235-244. https://doi.org/10.1177/0333102410378051
Lee Peterlin, B. ; Rosso, Andrea L. ; Sheftell, Fred D. ; Libon, David J. ; Mossey, Jana M. ; Merikangas, Kathleen R. / Post-traumatic stress disorder, drug abuse and migraine : New findings from the National Comorbidity Survey Replication (NCS-R). In: Cephalalgia. 2011 ; Vol. 31, No. 2. pp. 235-244.
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