Post-transplant lymphoproliferative disorder subtypes correlate with different recurring chromosomal abnormalities

Miroslav Djokic, Michelle M. Le Beau, Lode J. Swinnen, Sonali M. Smith, Charles M. Rubin, John Anastasi, Katrin M. Carlson

Research output: Contribution to journalArticlepeer-review

Abstract

Although cytogenetic analysis advanced the understanding of the pathogenesis of primary non-Hodgkin lymphoma and led to improved clinical management, there have been no large cytogenetic studies of post-transplant lymphoproliferative disorder (PTLD). We examined the karyotypes of 36 PTLD cases and correlated them with clinical, laboratory, and pathologic findings. The cases included 2 early lesions, 13 polymorphic PTLDs, and 21 monomorphic PTLDs (18 B-cell and 3 T-cell proliferations). Cytogenetic abnormalities were identified in 72% of monomorphic B-cell PTLDs and in all T-cell PTLDs, but in only 15% of polymorphic PTLDs and in no early lesions. The most frequent clonal abnormalities in monomorphic PTLD were trisomies 9 and/or 11 (5 cases), followed by rearrangements of 8q24.1 (4 cases), 3q27 (2 cases), and 14q32 (2 cases). MYC rearrangement (8q24.1) and T-cell-associated chromosomal abnormalities correlated with poor outcome and short survival. PTLD with trisomy 9 and/or 11 developed early after transplant, presenting as Epstein-Barr virus-positive large B-cell lymphoma with prolonged survival.

Original languageEnglish (US)
Pages (from-to)313-318
Number of pages6
JournalGenes Chromosomes and Cancer
Volume45
Issue number3
DOIs
StatePublished - Mar 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

Fingerprint Dive into the research topics of 'Post-transplant lymphoproliferative disorder subtypes correlate with different recurring chromosomal abnormalities'. Together they form a unique fingerprint.

Cite this