Sager et al. show that casein-kinase-2-mediated sequential phosphorylation of the co-chaperone FNIP1 leads to incremental inhibition of Hsp90 ATPase activity and gradual activation of both kinase and non-kinase clients. O-GlcNAcylation antagonizes phosphorylation of FNIP1, preventing its interaction with Hsp90, and consequently promotes FNIP1 ubiquitination and proteasomal degradation.
- Birt-Hogg-Dubé syndrome
- folliculin-interacting protein 1
- heat shock protein 90
- serine/threonine protein phosphatase 5
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)