Post-translational modifications of ATP synthase in the heart: Biology and function

Lesley A. Kane; Jennifer E. Van Eyk

doi:10.1007/s10863-009-9218-6

Post-translational modifications of ATP synthase in the heart: Biology and function

Lesley A. Kane, Jennifer E. Van Eyk

Research output: Contribution to journal › Review article › peer-review

31 Scopus citations

Abstract

The ATP synthase complex is a critical enzyme in the energetic pathways of cells because it is the enzyme complex that produces the majority of cellular ATP. It has been shown to be involved in several cardiac phenotypes including heart failure and preconditioning, a cellular protective mechanism. Understanding the regulation of this enzyme is important in understanding the mechanisms behind these important phenomena. Recently there have been several post-translational modifications (PTM) reported for various subunits of this enzyme complex, opening up the possibility of differential regulation by these PTMs. Here we discuss the known PTMs in the heart and other mammalian tissues and their implication to function and regulation of the ATP synthase.

Original language	English (US)
Pages (from-to)	145-150
Number of pages	6
Journal	Journal of Bioenergetics and Biomembranes
Volume	41
Issue number	2
DOIs	https://doi.org/10.1007/s10863-009-9218-6
State	Published - Apr 2009
Externally published	Yes

Keywords

ATP synthase
Heart
Post-translational modification

ASJC Scopus subject areas

Physiology
Cell Biology

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10.1007/s10863-009-9218-6

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abstract = "The ATP synthase complex is a critical enzyme in the energetic pathways of cells because it is the enzyme complex that produces the majority of cellular ATP. It has been shown to be involved in several cardiac phenotypes including heart failure and preconditioning, a cellular protective mechanism. Understanding the regulation of this enzyme is important in understanding the mechanisms behind these important phenomena. Recently there have been several post-translational modifications (PTM) reported for various subunits of this enzyme complex, opening up the possibility of differential regulation by these PTMs. Here we discuss the known PTMs in the heart and other mammalian tissues and their implication to function and regulation of the ATP synthase.",

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AB - The ATP synthase complex is a critical enzyme in the energetic pathways of cells because it is the enzyme complex that produces the majority of cellular ATP. It has been shown to be involved in several cardiac phenotypes including heart failure and preconditioning, a cellular protective mechanism. Understanding the regulation of this enzyme is important in understanding the mechanisms behind these important phenomena. Recently there have been several post-translational modifications (PTM) reported for various subunits of this enzyme complex, opening up the possibility of differential regulation by these PTMs. Here we discuss the known PTMs in the heart and other mammalian tissues and their implication to function and regulation of the ATP synthase.

KW - ATP synthase

KW - Heart

KW - Post-translational modification

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Post-translational modifications of ATP synthase in the heart: Biology and function

Abstract

Keywords

ASJC Scopus subject areas

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