Post-translational modifications of ATP synthase in the heart: Biology and function

Lesley A. Kane, Jennifer E. Van Eyk

Research output: Contribution to journalReview articlepeer-review


The ATP synthase complex is a critical enzyme in the energetic pathways of cells because it is the enzyme complex that produces the majority of cellular ATP. It has been shown to be involved in several cardiac phenotypes including heart failure and preconditioning, a cellular protective mechanism. Understanding the regulation of this enzyme is important in understanding the mechanisms behind these important phenomena. Recently there have been several post-translational modifications (PTM) reported for various subunits of this enzyme complex, opening up the possibility of differential regulation by these PTMs. Here we discuss the known PTMs in the heart and other mammalian tissues and their implication to function and regulation of the ATP synthase.

Original languageEnglish (US)
Pages (from-to)145-150
Number of pages6
JournalJournal of Bioenergetics and Biomembranes
Issue number2
StatePublished - Apr 2009
Externally publishedYes


  • ATP synthase
  • Heart
  • Post-translational modification

ASJC Scopus subject areas

  • Physiology
  • Cell Biology


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