Post-sequelae symptoms and comorbidities after COVID-19

Priya Duggal, Tristan Penson, Hannah N. Manley, Candelaria Vergara, Rebecca M. Munday, Dylan Duchen, Elizabeth A. Linton, Amber Zurn, Jeanne C. Keruly, Shruti H. Mehta, David L. Thomas

Research output: Contribution to journalArticlepeer-review


The frequency, severity, and forms of symptoms months after coronavirus 2019 (COVID-19) are poorly understood, especially in community settings. To better understand and characterize symptoms months after community-based COVID-19, a retrospective cohort analysis was conducted. Three hundred and twenty-eight consecutive persons with a positive test for SARS-CoV-2 in the Johns Hopkins Health System, Maryland, March−May 2020, were selected for the study. Symptom occurrence and severity were measured through questionnaires. Of 328 persons evaluated, a median of 242 days (109−478 days) from the initial positive SARS-CoV-2 test, 33.2% reported not being fully recovered and 4.9% reported symptoms that constrained daily activities. Compared to those who reported being fully recovered, those with post-acute sequelae were more likely to report a prior history of heart attack (p < 0.01). Among those reporting long-term symptoms, men and women were equally represented (men = 34.8%, women = 34.6%), but only women reported symptoms that constrained daily activities, and 56% of them were caregivers. The types of new or persistent symptoms varied, and for many, included a deviation from prior COVID-19 health, such as being less able to exercise, walk, concentrate, or breathe. A limitation is that self-report of symptoms might be biased and/or caused by factors other than COVID-19. Overall, even in a community setting, symptoms may persist months after COVID-19 reducing daily activities including caring for dependents.

Original languageEnglish (US)
Pages (from-to)2060-2066
Number of pages7
JournalJournal of Medical Virology
Issue number5
StatePublished - May 2022


  • SARS-CoV-2
  • long-haul
  • post-COVID-19
  • sequela

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology


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