Proteccion de la funcion miocardica post-isquemia por el vino tinto Cabernet-Sauvignon Argentino

Translated title of the contribution: Post-ischemic myocardial protection with Argentine Cabernet-Sauvignon red wine

Susana M. Mosca, Horacio E. Cingolani

Research output: Contribution to journalArticle

Abstract

The objective was to assess the action of two Argentine (from Mendoza) non-alcoholic red wine extracts (Cabernet-Sauvignon (CS) and a generic control (G)) on myocardial stunning that follows the reperfusion period. In the isolated isovolumically perfused rat heart the recovery of systolic and diastolic functions after 20 min of global ischemia were assessed through left ventricular developed pressure (LVDP) and end diastolic pressure (EDP), respectively. After 30 min of reperfusion LVDP recovered to 66 ± 7% in control ischemic hearts. The administration of non-alcoholic extract of CS not of G wine significantly increased the post-ischemic recovery (101 ± 4%, p <0.05) of the hearts. The ischemic contracture was not modified by either of the wines. However, during reperfusion the CS, not the G wine, decreased significantly the increase in EDP observed in control ischemic hearts. These results present experimental evidence that the non-alcoholic extracts of CS and not of G Argentine red wine induces protection of postischemic myocardial function.

Original languageSpanish
Pages (from-to)609-612
Number of pages4
JournalMedicina
Volume60
Issue number5
StatePublished - 2000
Externally publishedYes

Fingerprint

Wine
Reperfusion
Ventricular Pressure
Ischemic Contracture
Myocardial Stunning
Blood Pressure
Ischemia

Keywords

  • Argentine Cabernet-Sauvignon
  • Diastolic function
  • Myocardial stunning
  • Red wine
  • Systolic function

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Proteccion de la funcion miocardica post-isquemia por el vino tinto Cabernet-Sauvignon Argentino. / Mosca, Susana M.; Cingolani, Horacio E.

In: Medicina, Vol. 60, No. 5, 2000, p. 609-612.

Research output: Contribution to journalArticle

Mosca, Susana M. ; Cingolani, Horacio E. / Proteccion de la funcion miocardica post-isquemia por el vino tinto Cabernet-Sauvignon Argentino. In: Medicina. 2000 ; Vol. 60, No. 5. pp. 609-612.
@article{468ad5f9896c4e7692306c6a8f8abf97,
title = "Proteccion de la funcion miocardica post-isquemia por el vino tinto Cabernet-Sauvignon Argentino",
abstract = "The objective was to assess the action of two Argentine (from Mendoza) non-alcoholic red wine extracts (Cabernet-Sauvignon (CS) and a generic control (G)) on myocardial stunning that follows the reperfusion period. In the isolated isovolumically perfused rat heart the recovery of systolic and diastolic functions after 20 min of global ischemia were assessed through left ventricular developed pressure (LVDP) and end diastolic pressure (EDP), respectively. After 30 min of reperfusion LVDP recovered to 66 ± 7{\%} in control ischemic hearts. The administration of non-alcoholic extract of CS not of G wine significantly increased the post-ischemic recovery (101 ± 4{\%}, p <0.05) of the hearts. The ischemic contracture was not modified by either of the wines. However, during reperfusion the CS, not the G wine, decreased significantly the increase in EDP observed in control ischemic hearts. These results present experimental evidence that the non-alcoholic extracts of CS and not of G Argentine red wine induces protection of postischemic myocardial function.",
keywords = "Argentine Cabernet-Sauvignon, Diastolic function, Myocardial stunning, Red wine, Systolic function",
author = "Mosca, {Susana M.} and Cingolani, {Horacio E.}",
year = "2000",
language = "Spanish",
volume = "60",
pages = "609--612",
journal = "Medicina",
issn = "0025-7680",
publisher = "Instituto de Investigaciones Medicas",
number = "5",

}

TY - JOUR

T1 - Proteccion de la funcion miocardica post-isquemia por el vino tinto Cabernet-Sauvignon Argentino

AU - Mosca, Susana M.

AU - Cingolani, Horacio E.

PY - 2000

Y1 - 2000

N2 - The objective was to assess the action of two Argentine (from Mendoza) non-alcoholic red wine extracts (Cabernet-Sauvignon (CS) and a generic control (G)) on myocardial stunning that follows the reperfusion period. In the isolated isovolumically perfused rat heart the recovery of systolic and diastolic functions after 20 min of global ischemia were assessed through left ventricular developed pressure (LVDP) and end diastolic pressure (EDP), respectively. After 30 min of reperfusion LVDP recovered to 66 ± 7% in control ischemic hearts. The administration of non-alcoholic extract of CS not of G wine significantly increased the post-ischemic recovery (101 ± 4%, p <0.05) of the hearts. The ischemic contracture was not modified by either of the wines. However, during reperfusion the CS, not the G wine, decreased significantly the increase in EDP observed in control ischemic hearts. These results present experimental evidence that the non-alcoholic extracts of CS and not of G Argentine red wine induces protection of postischemic myocardial function.

AB - The objective was to assess the action of two Argentine (from Mendoza) non-alcoholic red wine extracts (Cabernet-Sauvignon (CS) and a generic control (G)) on myocardial stunning that follows the reperfusion period. In the isolated isovolumically perfused rat heart the recovery of systolic and diastolic functions after 20 min of global ischemia were assessed through left ventricular developed pressure (LVDP) and end diastolic pressure (EDP), respectively. After 30 min of reperfusion LVDP recovered to 66 ± 7% in control ischemic hearts. The administration of non-alcoholic extract of CS not of G wine significantly increased the post-ischemic recovery (101 ± 4%, p <0.05) of the hearts. The ischemic contracture was not modified by either of the wines. However, during reperfusion the CS, not the G wine, decreased significantly the increase in EDP observed in control ischemic hearts. These results present experimental evidence that the non-alcoholic extracts of CS and not of G Argentine red wine induces protection of postischemic myocardial function.

KW - Argentine Cabernet-Sauvignon

KW - Diastolic function

KW - Myocardial stunning

KW - Red wine

KW - Systolic function

UR - http://www.scopus.com/inward/record.url?scp=0034572520&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034572520&partnerID=8YFLogxK

M3 - Article

C2 - 11188902

AN - SCOPUS:0034572520

VL - 60

SP - 609

EP - 612

JO - Medicina

JF - Medicina

SN - 0025-7680

IS - 5

ER -