Post-infectious and post-vaccinal disorders of the central nervous system

Research output: Contribution to journalArticlepeer-review

Abstract

EAE, post-Semple rabies vaccine encephalomyelitis, and post-infectious encephalomyelitis share a common pathology, monophasic clinical course, and immune reactivity to myelin proteins, particularly MBP. Two of these diseases are induced by inoculation of neural tisssue. The mechanism of induction of autoimmune reactivity in post-infectious encephalomyelitis is not as yet understood. It is possible that virus-induced altered immune regulation, altered antigen presentation within the CNS, genetic factors, and cross-reactivity of viral and neural proteins may all play a role in the development of this neurologic disease.

Original languageEnglish (US)
Pages (from-to)239-249
Number of pages11
JournalImmunology and Allergy Clinics of North America
Volume8
Issue number2
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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