Post-ECT increases in MRI regional T2 relaxation times and their relationship to cognitive side effects: A pilot study

David J. Diehl, Matcheri S. Keshavan, Emanuel Kanal, Robert D. Nebes, Thomas E. Nichols, Joseph S. Gillen

Research output: Contribution to journalArticlepeer-review


This pilot study examined the hypothesis that magnetic resonance imaging T2 relaxation times of specific brain regions increase after electroconvulsive therapy (ECT) and that these increases are related to the cognitive side effects of ECT. Six depressed patients undergoing unilateral ECT were studied. The results demonstrate significant post-ECT T2 increases in the right and left thalumus, and suggest a correlation between regional T2 increase and anterograde memory impairment following ECT. These findings are consistent with a post-ECT increase in brain water content (perhaps secondary to a breakdown of the blood-brain barrier) and suggest that this process may be related to the memory impairment following ECT.

Original languageEnglish (US)
Pages (from-to)177-184
Number of pages8
JournalPsychiatry research
Issue number2
StatePublished - Nov 1994
Externally publishedYes


  • Affective disorder
  • ECT
  • magnetic resonance imaging
  • memory
  • thalamus

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Fingerprint Dive into the research topics of 'Post-ECT increases in MRI regional T<sub>2</sub> relaxation times and their relationship to cognitive side effects: A pilot study'. Together they form a unique fingerprint.

Cite this