Post-cardiac arrest encephalopathy

Wei Xiong, Robert E. Hoesch, Romergryko G. Geocadin

Research output: Contribution to journalArticlepeer-review


Brain injury continues to be a leading cause of mortality and morbidity in patients resuscitated after cardiac arrest. During periods of hypoxia and ischemia, numerous mechanisms contribute to the initial and secondary injury of the brain. Though many drugs and therapies have been evaluated for neuroprotection, only therapeutic hypothermia has been proven to be effective. Accurate prognostication after cardiac arrest is essential, and can be achieved with careful neurologic examination and several ancillary tests utilizing neurophysiology, neuroimaging, and biochemistry. Practice guidelines are now available for prognostication and postresuscitation care, with emphasis on improving survival and quality of life. Also reviewed are a wide spectrum of postarrest neurologic complications and their targeted treatments.

Original languageEnglish (US)
Pages (from-to)216-225
Number of pages10
JournalSeminars in neurology
Issue number2
StatePublished - 2011


  • Cardiac arrest
  • anoxic
  • encephalopathy
  • hypoxic
  • hypoxic-ischemic
  • ischemic

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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