Possible sources of endothelin-1 in damaged rat brain

Goro Yamada, Hiroshi Hama, Yoshitoshi Kasuya, Tomoh Masaki, Katsutoshi Goto

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


We investigated the sources of endothelin-1 (ET-1) detected in the damaged brain tissue of rats after cold injury. ET-1 in the injured sites was increased 1-5 days after the injury. Physiologic observations revealed that breakdown of the blood-brain barrier occurred and that plasma-derived albumin exuded into the brain parenchyma after cold injury. Radiolabeled ET-1, which was injected into the left cardiac ventricle, was detected in the tissue at the injury site, and ET-1-like immunoreactivity was observed in the brain capillaries in the damaged tissues. TGF-β1, which is a tissue regeneration factor, potently induced the expression of ET-1 mRNA in cultured astrocytes. These results suggest that ET-1 is produced through a variety of ways in the damaged brain.

Original languageEnglish (US)
Pages (from-to)S486-S490
JournalJournal of cardiovascular pharmacology
StatePublished - 1995


  • Cold injury
  • Endothelin
  • Rat brain
  • Source

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine


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