Possible sources of endothelin-1 in damaged rat brain

Goro Yamada; Hiroshi Hama; Yoshitoshi Kasuya; Tomoh Masaki; Katsutoshi Goto

doi:10.1097/00005344-199526003-00143

Possible sources of endothelin-1 in damaged rat brain

Goro Yamada, Hiroshi Hama, Yoshitoshi Kasuya, Tomoh Masaki, Katsutoshi Goto

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated the sources of endothelin-1 (ET-1) detected in the damaged brain tissue of rats after cold injury. ET-1 in the injured sites was increased 1-5 days after the injury. Physiologic observations revealed that breakdown of the blood-brain barrier occurred and that plasma-derived albumin exuded into the brain parenchyma after cold injury. Radiolabeled ET-1, which was injected into the left cardiac ventricle, was detected in the tissue at the injury site, and ET-1-like immunoreactivity was observed in the brain capillaries in the damaged tissues. TGF-β1, which is a tissue regeneration factor, potently induced the expression of ET-1 mRNA in cultured astrocytes. These results suggest that ET-1 is produced through a variety of ways in the damaged brain.

Original language	English (US)
Pages (from-to)	S486-S490
Journal	Journal of cardiovascular pharmacology
Volume	26
DOIs	https://doi.org/10.1097/00005344-199526003-00143
State	Published - 1995

Keywords

Cold injury
Endothelin
Rat brain
Source

ASJC Scopus subject areas

Pharmacology
Cardiology and Cardiovascular Medicine

Access to Document

10.1097/00005344-199526003-00143

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title = "Possible sources of endothelin-1 in damaged rat brain",

abstract = "We investigated the sources of endothelin-1 (ET-1) detected in the damaged brain tissue of rats after cold injury. ET-1 in the injured sites was increased 1-5 days after the injury. Physiologic observations revealed that breakdown of the blood-brain barrier occurred and that plasma-derived albumin exuded into the brain parenchyma after cold injury. Radiolabeled ET-1, which was injected into the left cardiac ventricle, was detected in the tissue at the injury site, and ET-1-like immunoreactivity was observed in the brain capillaries in the damaged tissues. TGF-β1, which is a tissue regeneration factor, potently induced the expression of ET-1 mRNA in cultured astrocytes. These results suggest that ET-1 is produced through a variety of ways in the damaged brain.",

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AU - Hama, Hiroshi

AU - Kasuya, Yoshitoshi

AU - Masaki, Tomoh

AU - Goto, Katsutoshi

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