Possible role of the fetal adrenal glands in the etiology of postmaturity

Uchenna Nwosu, Edward E Wallach, Thomas R. Boggs, Richard L. Nemiroff, Alfred M. Bongiovanni

Research output: Contribution to journalArticle

Abstract

Plasma cortisol levels were studied in the cord blood and neonatal blood of the following vaginally delivered groups: (A) postmature; (B) postterm (but not postmature); and (C) term neonates. Significantly lower levels of 8 a.m. neonatal plasma cortisol were found in postmature neonates when compared with term neonates (P <0.02) or merely postterm neonates (P <0.02). No difference was found in the cord blood cortisol levels in all three groups. Contrary to the traditional belief that postmaturity results from placental aging, our findings appear to indicate that postmaturity represents a specific fetal disorder. Fetal adrenal insufficiency may be a characteristic of this disorder. Prolonged pregnancy in these cases may reflect inability of the affected fetus to initiate labor.

Original languageEnglish (US)
Pages (from-to)366-370
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume121
Issue number3
StatePublished - Feb 1 1975
Externally publishedYes

Fingerprint

Adrenal Glands
Newborn Infant
Hydrocortisone
Fetal Blood
Prolonged Pregnancy
Adrenal Insufficiency
Fetus

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Nwosu, U., Wallach, E. E., Boggs, T. R., Nemiroff, R. L., & Bongiovanni, A. M. (1975). Possible role of the fetal adrenal glands in the etiology of postmaturity. American Journal of Obstetrics and Gynecology, 121(3), 366-370.

Possible role of the fetal adrenal glands in the etiology of postmaturity. / Nwosu, Uchenna; Wallach, Edward E; Boggs, Thomas R.; Nemiroff, Richard L.; Bongiovanni, Alfred M.

In: American Journal of Obstetrics and Gynecology, Vol. 121, No. 3, 01.02.1975, p. 366-370.

Research output: Contribution to journalArticle

Nwosu, U, Wallach, EE, Boggs, TR, Nemiroff, RL & Bongiovanni, AM 1975, 'Possible role of the fetal adrenal glands in the etiology of postmaturity', American Journal of Obstetrics and Gynecology, vol. 121, no. 3, pp. 366-370.
Nwosu, Uchenna ; Wallach, Edward E ; Boggs, Thomas R. ; Nemiroff, Richard L. ; Bongiovanni, Alfred M. / Possible role of the fetal adrenal glands in the etiology of postmaturity. In: American Journal of Obstetrics and Gynecology. 1975 ; Vol. 121, No. 3. pp. 366-370.
@article{2f239078695d47d093b78bff22649fde,
title = "Possible role of the fetal adrenal glands in the etiology of postmaturity",
abstract = "Plasma cortisol levels were studied in the cord blood and neonatal blood of the following vaginally delivered groups: (A) postmature; (B) postterm (but not postmature); and (C) term neonates. Significantly lower levels of 8 a.m. neonatal plasma cortisol were found in postmature neonates when compared with term neonates (P <0.02) or merely postterm neonates (P <0.02). No difference was found in the cord blood cortisol levels in all three groups. Contrary to the traditional belief that postmaturity results from placental aging, our findings appear to indicate that postmaturity represents a specific fetal disorder. Fetal adrenal insufficiency may be a characteristic of this disorder. Prolonged pregnancy in these cases may reflect inability of the affected fetus to initiate labor.",
author = "Uchenna Nwosu and Wallach, {Edward E} and Boggs, {Thomas R.} and Nemiroff, {Richard L.} and Bongiovanni, {Alfred M.}",
year = "1975",
month = "2",
day = "1",
language = "English (US)",
volume = "121",
pages = "366--370",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "3",

}

TY - JOUR

T1 - Possible role of the fetal adrenal glands in the etiology of postmaturity

AU - Nwosu, Uchenna

AU - Wallach, Edward E

AU - Boggs, Thomas R.

AU - Nemiroff, Richard L.

AU - Bongiovanni, Alfred M.

PY - 1975/2/1

Y1 - 1975/2/1

N2 - Plasma cortisol levels were studied in the cord blood and neonatal blood of the following vaginally delivered groups: (A) postmature; (B) postterm (but not postmature); and (C) term neonates. Significantly lower levels of 8 a.m. neonatal plasma cortisol were found in postmature neonates when compared with term neonates (P <0.02) or merely postterm neonates (P <0.02). No difference was found in the cord blood cortisol levels in all three groups. Contrary to the traditional belief that postmaturity results from placental aging, our findings appear to indicate that postmaturity represents a specific fetal disorder. Fetal adrenal insufficiency may be a characteristic of this disorder. Prolonged pregnancy in these cases may reflect inability of the affected fetus to initiate labor.

AB - Plasma cortisol levels were studied in the cord blood and neonatal blood of the following vaginally delivered groups: (A) postmature; (B) postterm (but not postmature); and (C) term neonates. Significantly lower levels of 8 a.m. neonatal plasma cortisol were found in postmature neonates when compared with term neonates (P <0.02) or merely postterm neonates (P <0.02). No difference was found in the cord blood cortisol levels in all three groups. Contrary to the traditional belief that postmaturity results from placental aging, our findings appear to indicate that postmaturity represents a specific fetal disorder. Fetal adrenal insufficiency may be a characteristic of this disorder. Prolonged pregnancy in these cases may reflect inability of the affected fetus to initiate labor.

UR - http://www.scopus.com/inward/record.url?scp=0016439052&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016439052&partnerID=8YFLogxK

M3 - Article

C2 - 1115150

AN - SCOPUS:0016439052

VL - 121

SP - 366

EP - 370

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 3

ER -