Possible role of IgE-mediated reaction in immunity

Paul Steinberg, Kimishige Ishizaka, Philip S. Norman

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


The effect of a local IgE-mediated hypersensitivity reaction on the neutralization of diphtheria, toxin at skin sites was studied in monkeys passively immunized with human IgG antitoxin. When a mixture of toxin with ragweed allergen was injected intracutaneously into skin sites that had been sensitized with serum from ragweedsensitive patients, the sensitized sites tolerated a significantly greater dose of toxin than did unsensitized sites. An injection of anti-IgE, which induced reversed-type reaginic hypersensitivity reaction, together with the challenging toxin, similarly increased the toxin-neutralizing capacity of the skin sites. In nonimmunized animals, however, IgE-mediated reactions did not show any effect on local resistance. The results indicated that an increased toxin-neutralizing capacity of the local skin sites in passively immunized animals was due to translocation of serum IgG antibody into the skin sites rather than a possible dilution of the toxin by edema fluid. A possible "gatekeeper" role of IgE antibody system in local immunity of mucosal systems was discussed.

Original languageEnglish (US)
Pages (from-to)359-366
Number of pages8
JournalThe Journal of allergy and clinical immunology
Issue number6
StatePublished - Dec 1974

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


Dive into the research topics of 'Possible role of IgE-mediated reaction in immunity'. Together they form a unique fingerprint.

Cite this